Diagnostic Efficacy of Gadoxetic Acid-enhanced MRI in the Detection of Hepatocellular Carcinomas: Comparison with Gadopentetate Dimeglumine

Overview

Journal Br J Radiol

Publisher Oxford University Press

Specialty Radiology

Date 2010 Aug 5

PMID 20682591

Citations 29

Authors

G Park

Y K Kim

C S Kim

H C Yu

S B Hwang

Affiliations

Soon will be listed here.

Abstract

This study compared the efficacy of gadoxetic acid-enhanced MRI and gadopentetate dimeglumine-enhanced MRI in the detection of small hepatocellular carcinoma (HCC). Both MRI techniques were performed on 43 patients with a total of 59 HCCs (size range, 0.5-2.0 cm), with a mean interval between the two MRI studies of 3 days (range, 2-7 days). Two observers reviewed both data sets in consensus. Diagnostic accuracy and sensitivity were evaluated using the alternative-free response receiver operator characteristic (ROC) method. The gadoxetic acid set showed a trend toward increased area under the ROC curve (Az value = 0.958) compared with the gadopentetate dimeglumine set (Az value = 0.927), but the difference was not significant (p = 0.362). The sensitivity of the gadoxetic acid set (n = 51, 86.4%) was significantly higher than that of the gadopentetate dimeglumine set (n = 38, 64.4%) (p = 0.0001). Gadoxetic acid-enhanced MRI is a more sensitive diagnostic tool for detection of HCC than gadopentetate dimeglumine-enhanced MRI.

Citing Articles

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References

Jung G, Breuer J, Poll L, Koch J, Balzer T, Chang S . Imaging characteristics of hepatocellular carcinoma using the hepatobiliary contrast agent Gd-EOB-DTPA. Acta Radiol. 2006; 47(1):15-23. DOI: 10.1080/02841850500406795. View

Chakraborty D, Winter L . Free-response methodology: alternate analysis and a new observer-performance experiment. Radiology. 1990; 174(3 Pt 1):873-81. DOI: 10.1148/radiology.174.3.2305073. View

Grazioli L, OLIVETTI L, Fugazzola C, Benetti A, Stanga C, Dettori E . The pseudocapsule in hepatocellular carcinoma: correlation between dynamic MR imaging and pathology. Eur Radiol. 1999; 9(1):62-7. DOI: 10.1007/s003300050629. View

Halavaara J, Breuer J, Ayuso C, Balzer T, Bellin M, Blomqvist L . Liver tumor characterization: comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT--a multicenter trial. J Comput Assist Tomogr. 2006; 30(3):345-54. DOI: 10.1097/00004728-200605000-00001. View

Tanimoto A, Satoh Y, Yuasa Y, Jinzaki M, Hiramatsu K . Performance of Gd-EOB-DTPA and superparamagnetic iron oxide particles in the detection of primary liver cancer: a comparative study by alternative free-response receiver operating characteristic analysis. J Magn Reson Imaging. 1997; 7(1):120-4. DOI: 10.1002/jmri.1880070116. View

Huppertz A, Haraida S, Kraus A, Zech C, Scheidler J, Breuer J . Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: correlation with histopathologic findings and spiral CT--initial observations. Radiology. 2004; 234(2):468-78. DOI: 10.1148/radiol.2342040278. View

Lencioni R, Pinto F, Armillotta N, Di Giulio M, Gaeta P, Di Candio G . Intrahepatic metastatic nodules of hepatocellular carcinoma detected at lipiodol-CT: imaging-pathologic correlation. Abdom Imaging. 1997; 22(3):253-8. DOI: 10.1007/s002619900183. View

Huppertz A, Balzer T, Blakeborough A, Breuer J, Giovagnoni A, Heinz-Peer G . Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Radiology. 2003; 230(1):266-75. DOI: 10.1148/radiol.2301020269. View

Bruix J, Sherman M . Management of hepatocellular carcinoma. Hepatology. 2005; 42(5):1208-36. DOI: 10.1002/hep.20933. View

10.

Kim Y, Kwak H, Han Y, Kim C . Usefulness of combining sequentially acquired gadobenate dimeglumine-enhanced magnetic resonance imaging and resovist-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: comparison with computed tomography hepatic.... J Comput Assist Tomogr. 2007; 31(5):702-11. DOI: 10.1097/RCT.0b013e31802d0b6b. View

11.

Ward J, Guthrie J, Scott D, Atchley J, Wilson D, Davies M . Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis. Radiology. 2000; 216(1):154-62. DOI: 10.1148/radiology.216.1.r00jl24154. View

12.

Kim T, Murakami T, Oi H, Matsushita M, Kishimoto H, Igarashi H . Detection of hypervascular hepatocellular carcinoma by dynamic MRI and dynamic spiral CT. J Comput Assist Tomogr. 1995; 19(6):948-54. DOI: 10.1097/00004728-199511000-00020. View

13.

EDMONDSON H, STEINER P . Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954; 7(3):462-503. DOI: 10.1002/1097-0142(195405)7:3<462::aid-cncr2820070308>3.0.co;2-e. View

14.

Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann H . Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol. 2005; 40(11):715-24. DOI: 10.1097/01.rli.0000184756.66360.d3. View

15.

Kim Y, Lee Y, Kwak H, Kim C, Han Y . Clinical implication of small (<20 mm) enhancing hepatic nodules observed only during three-dimensional gadobenate dimeglumine-enhanced hepatic arterial-phase MRI of the hepatitis B virus-induced mild cirrhosis. Clin Imaging. 2008; 32(6):453-9. DOI: 10.1016/j.clinimag.2008.05.002. View

16.

Rao J, Scott A . A simple method for the analysis of clustered binary data. Biometrics. 1992; 48(2):577-85. View

17.

Hammerstingl R, Huppertz A, Breuer J, Balzer T, Blakeborough A, Carter R . Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions. Eur Radiol. 2007; 18(3):457-67. DOI: 10.1007/s00330-007-0716-9. View

18.

Reimer P, Rummeny E, Daldrup H, Hesse T, Balzer T, Tombach B . Enhancement characteristics of liver metastases, hepatocellular carcinomas, and hemangiomas with Gd-EOB-DTPA: preliminary results with dynamic MR imaging. Eur Radiol. 1997; 7(2):275-80. DOI: 10.1007/s003300050150. View

19.

Holland A, Hecht E, Hahn W, Kim D, Babb J, Lee V . Importance of small (< or = 20-mm) enhancing lesions seen only during the hepatic arterial phase at MR imaging of the cirrhotic liver: evaluation and comparison with whole explanted liver. Radiology. 2005; 237(3):938-44. DOI: 10.1148/radiol.2373041364. View

20.

van Leeuwen M, Noordzij J, Feldberg M, Hennipman A, Doornewaard H . Focal liver lesions: characterization with triphasic spiral CT. Radiology. 1996; 201(2):327-36. DOI: 10.1148/radiology.201.2.8888219. View