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Emerging Advances in Rapid Diagnostics of Respiratory Infections

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Date 2010 Aug 3
PMID 20674804
Citations 11
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Abstract

Recent developments in rapid diagnostics for respiratory infections have mostly occurred in the areas of antigen and nucleic acid detection. Nucleic acid amplification tests have improved the ability to identify respiratory viruses in clinical specimens and have played pivotal roles in the rapid characterization of new viral pathogens. Antigen-detection assays in immunochromatographic or similar formats are most easily developed as near-patient tests, although they have been developed commercially only for a limited range of respiratory pathogens. New approaches for respiratory pathogen detection are needed, and breath analysis is an exciting area with enormous potential.

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References
1.
Quan P, Palacios G, Jabado O, Conlan S, Hirschberg D, Pozo F . Detection of respiratory viruses and subtype identification of influenza A viruses by GreeneChipResp oligonucleotide microarray. J Clin Microbiol. 2007; 45(8):2359-64. PMC: 1951265. DOI: 10.1128/JCM.00737-07. View

2.
Kais M, Spindler C, Kalin M, Ortqvist A, Giske C . Quantitative detection of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in lower respiratory tract samples by real-time PCR. Diagn Microbiol Infect Dis. 2006; 55(3):169-78. DOI: 10.1016/j.diagmicrobio.2006.01.007. View

3.
Ieven M . Currently used nucleic acid amplification tests for the detection of viruses and atypicals in acute respiratory infections. J Clin Virol. 2007; 40(4):259-76. PMC: 7108459. DOI: 10.1016/j.jcv.2007.08.012. View

4.
Raymond F, Carbonneau J, Boucher N, Robitaille L, Boisvert S, Wu W . Comparison of automated microarray detection with real-time PCR assays for detection of respiratory viruses in specimens obtained from children. J Clin Microbiol. 2009; 47(3):743-50. PMC: 2650908. DOI: 10.1128/JCM.01297-08. View

5.
Casiano-Colon A, Hulbert B, Mayer T, Walsh E, Falsey A . Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial virus infection in adults. J Clin Virol. 2003; 28(2):169-74. DOI: 10.1016/s1386-6532(03)00002-7. View