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The Other Janus Face of Qa-1 and HLA-E: Diverse Peptide Repertoires in Times of Stress

Overview
Journal Microbes Infect
Publisher Elsevier
Date 2010 Jul 31
PMID 20670688
Citations 33
Authors
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Abstract

The non-polymorphic MHC molecule Qa-1 and its human counterpart HLA-E present monomorphic signal peptides to innate receptors and thereby regulate lymphocyte activity. Under stress, this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins, infectious agents or antigen processing defects.

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