Mitochondria in Heart Failure

Overview

Journal Cardiovasc Res

Specialty Cardiology & Vascular Diseases

Date 2010 Jul 30

PMID 20668004

Citations 117

Authors

Mariana G Rosca

Charles L Hoppel

Affiliations

Soon will be listed here.

Abstract

This review focuses on the evidence accumulated in humans and animal models to the effect that mitochondria are key players in the progression of heart failure (HF). Mitochondria are the primary source of energy in the form of adenosine triphosphate that fuels the contractile apparatus, and are thus essential for the pumping activity of the heart. We evaluate changes in mitochondrial morphology and alterations in the main components of mitochondrial energetics, such as substrate utilization and oxidative phosphorylation coupled with the level of respirasomes, in the context of their contribution to the chronic energy deficit and mechanical dysfunction in HF.

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References

Recchia F, McConnell P, Bernstein R, Vogel T, Xu X, Hintze T . Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog. Circ Res. 1998; 83(10):969-79. DOI: 10.1161/01.res.83.10.969. View

Hoppel C, Tandler B, Parland W, Turkaly J, Albers L . Hamster cardiomyopathy. A defect in oxidative phosphorylation in the cardiac interfibrillar mitochondria. J Biol Chem. 1982; 257(3):1540-8. View

Miyazaki T, Neff L, Tanaka S, Horne W, Baron R . Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J Cell Biol. 2003; 160(5):709-18. PMC: 2173369. DOI: 10.1083/jcb.200209098. View

KADENBACH B, Huttemann M, Arnold S, Lee I, Bender E . Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase. Free Radic Biol Med. 2000; 29(3-4):211-21. DOI: 10.1016/s0891-5849(00)00305-1. View

Au H, Seo B, Yagi T, Scheffler I . The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria. Proc Natl Acad Sci U S A. 1999; 96(8):4354-9. PMC: 16336. DOI: 10.1073/pnas.96.8.4354. View

Nalecz K, Bolli R, Wojtczak L, Azzi A . The monocarboxylate carrier from bovine heart mitochondria: partial purification and its substrate-transporting properties in a reconstituted system. Biochim Biophys Acta. 1986; 851(1):29-37. DOI: 10.1016/0005-2728(86)90245-8. View

Riva A, Tandler B, Loffredo F, Vazquez E, Hoppel C . Structural differences in two biochemically defined populations of cardiac mitochondria. Am J Physiol Heart Circ Physiol. 2005; 289(2):H868-72. DOI: 10.1152/ajpheart.00866.2004. View

LEHMAN J, Barger P, Kovacs A, Saffitz J, Medeiros D, Kelly D . Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest. 2000; 106(7):847-56. PMC: 517815. DOI: 10.1172/JCI10268. View

Scacco S, Vergari R, Scarpulla R, Technikova-Dobrova Z, Sardanelli A, Lambo R . cAMP-dependent phosphorylation of the nuclear encoded 18-kDa (IP) subunit of respiratory complex I and activation of the complex in serum-starved mouse fibroblast cultures. J Biol Chem. 2000; 275(23):17578-82. DOI: 10.1074/jbc.M001174200. View

10.

Sanbe A, Tanonaka K, KOBAYASI R, Takeo S . Effects of long-term therapy with ACE inhibitors, captopril, enalapril and trandolapril, on myocardial energy metabolism in rats with heart failure following myocardial infarction. J Mol Cell Cardiol. 1995; 27(10):2209-22. DOI: 10.1016/s0022-2828(95)91551-6. View

11.

Rosca M, Vazquez E, Kerner J, Parland W, Chandler M, Stanley W . Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation. Cardiovasc Res. 2008; 80(1):30-9. PMC: 2533423. DOI: 10.1093/cvr/cvn184. View

12.

Lesnefsky E, Gudz T, Migita C, Hassan M, Turkaly P, Hoppel C . Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III. Arch Biochem Biophys. 2001; 385(1):117-28. DOI: 10.1006/abbi.2000.2066. View

13.

Sun C, Chang L, Sheu J, Wang C, Youssef A, Wu C . Losartan preserves integrity of cardiac gap junctions and PGC-1 alpha gene expression and prevents cellular apoptosis in remote area of left ventricular myocardium following acute myocardial infarction. Int Heart J. 2007; 48(4):533-46. DOI: 10.1536/ihj.48.533. View

14.

Weinstein E, Benson D, Fry D . Subpopulations of human heart mitochondria. J Surg Res. 1986; 40(5):495-8. DOI: 10.1016/0022-4804(86)90221-0. View

15.

Young M . The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function. Am J Physiol Heart Circ Physiol. 2005; 290(1):H1-16. DOI: 10.1152/ajpheart.00582.2005. View

16.

Sazanov L, Fearnley I, Walker J . Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme. Biochemistry. 2000; 39(24):7229-35. DOI: 10.1021/bi000335t. View

17.

Dabkowski E, Williamson C, Bukowski V, Chapman R, Leonard S, Peer C . Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations. Am J Physiol Heart Circ Physiol. 2008; 296(2):H359-69. PMC: 2643887. DOI: 10.1152/ajpheart.00467.2008. View

18.

Sardanelli A, Technikova-Dobrova Z, Scacco S, Speranza F, Papa S . Characterization of proteins phosphorylated by the cAMP-dependent protein kinase of bovine heart mitochondria. FEBS Lett. 1995; 377(3):470-4. DOI: 10.1016/0014-5793(95)01407-1. View

19.

Kemi O, Hoydal M, Haram P, Garnier A, Fortin D, Ventura-Clapier R . Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan. Cardiovasc Res. 2007; 76(1):91-9. DOI: 10.1016/j.cardiores.2007.06.008. View

20.

Pagliarini D, Wiley S, Kimple M, Dixon J, Kelly P, Worby C . Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell. 2005; 19(2):197-207. DOI: 10.1016/j.molcel.2005.06.008. View