Structural Basis for the Decrease in the Outward Potassium Channel Current Induced by Lanthanum

Overview

Journal J Biol Inorg Chem

Publisher Springer

Specialty Biochemistry

Date 2010 Jul 27

PMID 20658160

Citations 1

Authors

Li Hong Wang

Na Jiang

Bo Zhao

Xiao Dong Li

Tian Hong Lu

Xiao Lan Ding

Xiao Hua Huang

Affiliations

Soon will be listed here.

Abstract

The current of the outward K+ channel in the cell of horseradish treated with La3+ and the direct interaction between La3+ and the K+ channel protein were investigated using the whole-cell patch-clamp technique, molecular dynamics simulation, and quantum chemistry calculation methods. It was found for the first time that La3+ decreases the current of the K+ channel in the horseradish mesophyll cell. The decrease results from the formation of a coordination bond and hydrogen bond between La3+ and the K+ channel protein in the plasma membrane. The direct interaction destroys the native structure of the K+ channel protein, disturbing the function of the K+ channel protein in the cells. The results can provide the theoretical foundation for understanding the interaction between metal ions (especially high-valence metal ions) and the channel protein in organisms, including animal and plant cells.

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