Synthesis and Effect on Human HepG2 Cells of 1,2-bis-(2-methylallyl)disulfane

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2010 Jul 27

PMID 20657504

Authors

Chunxiao Ji

Fenglian Ren

Jun Dai

Ming Xu

Affiliations

Soon will be listed here.

Abstract

1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.

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