The Effects of Red and Blue Lights on Circadian Variations in Cortisol, Alpha Amylase, and Melatonin

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2010 Jul 24

PMID 20652045

Citations 38

Authors

Mariana G Figueiro

Mark S Rea

Affiliations

Soon will be listed here.

Abstract

The primary purpose of the present study was to expand our understanding of the impact of light exposures on the endocrine and autonomic systems as measured by acute cortisol, alpha amylase, and melatonin responses. We utilized exposures from narrowband long-wavelength (red) and from narrow-band short-wavelength (blue) lights to more precisely understand the role of the suprachiasmatic nuclei (SCN) in these responses. In a within-subjects experimental design, twelve subjects periodically received one-hour corneal exposures of 40 lux from the blue or from the red lights while continuously awake for 27 hours. Results showed-that, as expected, only the blue light reduced nocturnal melatonin. In contrast, both blue and red lights affected cortisol levels and, although less clear, alpha amylase levels as well. The present data bring into question whether the nonvisual pathway mediating nocturnal melatonin suppression is the same as that mediating other responses to light exhibited by the endocrine and the autonomic nervous systems.

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References

Strahler J, Mueller A, Rosenloecher F, Kirschbaum C, Rohleder N . Salivary alpha-amylase stress reactivity across different age groups. Psychophysiology. 2010; 47(3):587-95. DOI: 10.1111/j.1469-8986.2009.00957.x. View

Kaneko M, Hiroshige T, SHINSAKO J, Dallman M . Diurnal changes in amplification of hormone rhythms in the adrenocortical system. Am J Physiol. 1980; 239(3):R309-16. DOI: 10.1152/ajpregu.1980.239.3.R309. View

Granger D, Kivlighan K, El-Sheikh M, Gordis E, Stroud L . Salivary alpha-amylase in biobehavioral research: recent developments and applications. Ann N Y Acad Sci. 2007; 1098:122-44. DOI: 10.1196/annals.1384.008. View

Kalsbeek A, Drijfhout W, Westerink B, van Heerikhuize J, van der Woude T, van der Vliet J . GABA receptors in the region of the dorsomedial hypothalamus of rats are implicated in the control of melatonin and corticosterone release. Neuroendocrinology. 1996; 63(1):69-78. DOI: 10.1159/000126937. View

Scheer F, Buijs R . Light affects morning salivary cortisol in humans. J Clin Endocrinol Metab. 1999; 84(9):3395-8. DOI: 10.1210/jcem.84.9.6102. View

Thapan K, Arendt J, Skene D . An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol. 2001; 535(Pt 1):261-7. PMC: 2278766. DOI: 10.1111/j.1469-7793.2001.t01-1-00261.x. View

Szafarczyk A, Ixart G, Alonso G, Malaval F, Assenmacher I . CNS control of the circadian adrenocortical rhythm. J Steroid Biochem. 1983; 19(1C):1009-15. DOI: 10.1016/0022-4731(83)90047-x. View

Rea M, Figueiro M, Bullough J, Bierman A . A model of phototransduction by the human circadian system. Brain Res Brain Res Rev. 2005; 50(2):213-28. DOI: 10.1016/j.brainresrev.2005.07.002. View

Rohleder N, Nater U . Determinants of salivary alpha-amylase in humans and methodological considerations. Psychoneuroendocrinology. 2009; 34(4):469-85. DOI: 10.1016/j.psyneuen.2008.12.004. View

10.

Scheer F, van Doornen L, Buijs R . Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock. Auton Neurosci. 2004; 110(1):44-8. DOI: 10.1016/j.autneu.2003.03.001. View

11.

Schibler U, Brown S . Enlightening the adrenal gland. Cell Metab. 2005; 2(5):278-81. DOI: 10.1016/j.cmet.2005.10.001. View

12.

Nater U, Rohleder N, Schlotz W, Ehlert U, Kirschbaum C . Determinants of the diurnal course of salivary alpha-amylase. Psychoneuroendocrinology. 2007; 32(4):392-401. DOI: 10.1016/j.psyneuen.2007.02.007. View

13.

Leproult R, Colecchia E, LHermite-Baleriaux M, Van Cauter E . Transition from dim to bright light in the morning induces an immediate elevation of cortisol levels. J Clin Endocrinol Metab. 2001; 86(1):151-7. DOI: 10.1210/jcem.86.1.7102. View

14.

Rohleder N, Nater U, Wolf J, Ehlert U, Kirschbaum C . Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity?. Ann N Y Acad Sci. 2005; 1032:258-63. DOI: 10.1196/annals.1314.033. View

15.

Ishida A, Mutoh T, Ueyama T, Bando H, Masubuchi S, Nakahara D . Light activates the adrenal gland: timing of gene expression and glucocorticoid release. Cell Metab. 2005; 2(5):297-307. DOI: 10.1016/j.cmet.2005.09.009. View

16.

Buijs R, Wortel J, van Heerikhuize J, Kalsbeek A . Novel environment induced inhibition of corticosterone secretion: physiological evidence for a suprachiasmatic nucleus mediated neuronal hypothalamo-adrenal cortex pathway. Brain Res. 1997; 758(1-2):229-36. DOI: 10.1016/s0006-8993(97)00234-5. View

17.

Haus E . Chronobiology in the endocrine system. Adv Drug Deliv Rev. 2007; 59(9-10):985-1014. DOI: 10.1016/j.addr.2007.01.001. View

18.

McCARTHY J, CORLEY R, ZARROW M . Diurnal rhythm in plasma corticosterone and lack of diurnal rhythm in plasma compound F-like material in the rat. Proc Soc Exp Biol Med. 1960; 104:787-9. DOI: 10.3181/00379727-104-25988. View

19.

Kudielka B, Buchtal J, Uhde A, Wust S . Circadian cortisol profiles and psychological self-reports in shift workers with and without recent change in the shift rotation system. Biol Psychol. 2006; 74(1):92-103. DOI: 10.1016/j.biopsycho.2006.08.008. View

20.

Miller G, Chen E, Zhou E . If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull. 2007; 133(1):25-45. DOI: 10.1037/0033-2909.133.1.25. View