Successful Thrombolytic Therapy with Recombinant Tissue-type Plasminogen Activator for Massive Pulmonary Embolism -A Case Report-

Overview

Journal Korean J Anesthesiol

Specialty Anesthesiology

Date 2010 Jul 24

PMID 20652001

Citations 1

Authors

Min Soo Kim

Kye-Min Kim

Seung-Hoon Woo

Yun Hee Lim

Jun Heum Yon

Seung-Gyu Jeon

Affiliations

Soon will be listed here.

Abstract

Massive pulmonary embolism is associated with significant perioperative morbidity and mortality. We report here on a case of a 69-year-old man who suffered a massive pulmonary embolism with pulseless electrical activity during knee arthroscopic surgery. After a diagnosis was made by performing transthoracic echocardiography, the patient was treated with recombinant tissue-type plasminogen activator. The patient was transferred to the intensive care unit after his hemodynamic status improved. The patient went on to make a full cardiopulmonary recovery without any complications.

Citing Articles

Venous thromboembolism following arthroscopic knee surgery: a current concepts review of incidence, prophylaxis, and preoperative risk assessment.

Graham W, Flanigan D Sports Med. 2013; 44(3):331-43.

PMID: 24190733 DOI: 10.1007/s40279-013-0121-2.

References

Capstick T, Henry M . Efficacy of thrombolytic agents in the treatment of pulmonary embolism. Eur Respir J. 2005; 26(5):864-74. DOI: 10.1183/09031936.05.00002505. View

Bottiger B, Bohrer H, Bach A, Motsch J, Martin E . Bolus injection of thrombolytic agents during cardiopulmonary resuscitation for massive pulmonary embolism. Resuscitation. 1994; 28(1):45-54. DOI: 10.1016/0300-9572(94)90054-x. View

Farfel Z, Shechter M, Vered Z, Rath S, GOOR D, Gafni J . Review of echocardiographically diagnosed right heart entrapment of pulmonary emboli-in-transit with emphasis on management. Am Heart J. 1987; 113(1):171-8. DOI: 10.1016/0002-8703(87)90026-3. View

Clarke D, ABRAMS L . Pulmonary embolectomy: a 25 year experience. J Thorac Cardiovasc Surg. 1986; 92(3 Pt 1):442-5. View

Semba C, Bakal C, Calis K, GRUBBS G, Hunter D, Matalon T . Alteplase as an alternative to urokinase. Advisory Panel on Catheter-Directed Thrombolytic Therapy. J Vasc Interv Radiol. 2000; 11(3):279-87. DOI: 10.1016/s1051-0443(07)61418-3. View

Kanter D, Mikkola K, Patel S, Parker J, Goldhaber S . Thrombolytic therapy for pulmonary embolism. Frequency of intracranial hemorrhage and associated risk factors. Chest. 1997; 111(5):1241-5. DOI: 10.1378/chest.111.5.1241. View

Dauphine C, Omari B . Pulmonary embolectomy for acute massive pulmonary embolism. Ann Thorac Surg. 2005; 79(4):1240-4. DOI: 10.1016/j.athoracsur.2004.08.081. View

Kasper W, Meinertz T, Kersting F, Lollgen H, Limbourg P, Just H . Echocardiography in assessing acute pulmonary hypertension due to pulmonary embolism. Am J Cardiol. 1980; 45(3):567-72. DOI: 10.1016/s0002-9149(80)80006-3. View

Wood K . Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism. Chest. 2002; 121(3):877-905. DOI: 10.1378/chest.121.3.877. View

10.

Ullmann M, Hemmer W, Hannekum A . The urgent pulmonary embolectomy: mechanical resuscitation in the operating theatre determines the outcome. Thorac Cardiovasc Surg. 1999; 47(1):5-8. DOI: 10.1055/s-2007-1013099. View

11.

. British Thoracic Society guidelines for the management of suspected acute pulmonary embolism. Thorax. 2003; 58(6):470-83. PMC: 1746692. DOI: 10.1136/thorax.58.6.470. View

12.

Spohr F, Bottiger B . Safety of thrombolysis during cardiopulmonary resuscitation. Drug Saf. 2003; 26(6):367-79. DOI: 10.2165/00002018-200326060-00001. View

13.

Meyer G, Gisselbrecht M, Diehl J, Journois D, Sors H . Incidence and predictors of major hemorrhagic complications from thrombolytic therapy in patients with massive pulmonary embolism. Am J Med. 1998; 105(6):472-7. DOI: 10.1016/s0002-9343(98)00355-6. View

14.

Tayama E, Ouchida M, Teshima H, Takaseya T, Hiratsuka R, Akasu K . Treatment of acute massive/submassive pulmonary embolism. Circ J. 2002; 66(5):479-83. DOI: 10.1253/circj.66.479. View