Enteropathogenic Escherichia Coli, Samonella, Shigella and Yersinia: Cellular Aspects of Host-bacteria Interactions in Enteric Diseases

Overview

Journal Gut Pathog

Publisher Biomed Central

Specialty Gastroenterology

Date 2010 Jul 24

PMID 20649986

Citations 31

Authors

Roberta Souza Dos Reis

Fabiana Horn

Affiliations

Soon will be listed here.

Abstract

A successful infection of the human intestine by enteropathogenic bacteria depends on the ability of bacteria to attach and colonize the intestinal epithelium and, in some cases, to invade the host cell, survive intracellularly and disseminate from cell to cell. To accomplish these processes bacteria have evolved an arsenal of molecules that are mostly secreted by dedicated type III secretion systems, and that interact with the host, subverting normal cellular functions. Here we overview the most important molecular strategies developed by enteropathogenic Escherichia coli, Salmonella enterica, Shigella flexneri, and Yersinia enterocolitica to cause enteric infections. Despite having evolved different effectors, these four microorganisms share common host cellular targets.

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References

Watarai M, Funato S, Sasakawa C . Interaction of Ipa proteins of Shigella flexneri with alpha5beta1 integrin promotes entry of the bacteria into mammalian cells. J Exp Med. 1996; 183(3):991-9. PMC: 2192368. DOI: 10.1084/jem.183.3.991. View

Wong K, Isberg R . Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake. J Exp Med. 2003; 198(4):603-14. PMC: 2194175. DOI: 10.1084/jem.20021363. View

Bommarius B, Maxwell D, Swimm A, Leung S, Corbett A, Bornmann W . Enteropathogenic Escherichia coli Tir is an SH2/3 ligand that recruits and activates tyrosine kinases required for pedestal formation. Mol Microbiol. 2007; 63(6):1748-68. DOI: 10.1111/j.1365-2958.2007.05626.x. View

Schroeder G, Hilbi H . Cholesterol is required to trigger caspase-1 activation and macrophage apoptosis after phagosomal escape of Shigella. Cell Microbiol. 2006; 9(1):265-78. DOI: 10.1111/j.1462-5822.2006.00787.x. View

Guichon A, Hersh D, Smith M, Zychlinsky A . Structure-function analysis of the Shigella virulence factor IpaB. J Bacteriol. 2001; 183(4):1269-76. PMC: 95000. DOI: 10.1128/JB.183.4.1269-1276.2001. View

Skoudy A, Nhieu G, Mantis N, Arpin M, Mounier J, Gounon P . A functional role for ezrin during Shigella flexneri entry into epithelial cells. J Cell Sci. 1999; 112 ( Pt 13):2059-68. DOI: 10.1242/jcs.112.13.2059. View

Zumbihl R, Aepfelbacher M, Andor A, Jacobi C, Ruckdeschel K, Rouot B . The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA. J Biol Chem. 1999; 274(41):29289-93. DOI: 10.1074/jbc.274.41.29289. View

Paesold G, Guiney D, Eckmann L, Kagnoff M . Genes in the Salmonella pathogenicity island 2 and the Salmonella virulence plasmid are essential for Salmonella-induced apoptosis in intestinal epithelial cells. Cell Microbiol. 2002; 4(11):771-81. DOI: 10.1046/j.1462-5822.2002.00233.x. View

Eitel J, Heise T, Thiesen U, Dersch P . Cell invasion and IL-8 production pathways initiated by YadA of Yersinia pseudotuberculosis require common signalling molecules (FAK, c-Src, Ras) and distinct cell factors. Cell Microbiol. 2004; 7(1):63-77. DOI: 10.1111/j.1462-5822.2004.00434.x. View

10.

Lafont F, Tran van Nhieu G, Hanada K, Sansonetti P, van der Goot F . Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction. EMBO J. 2002; 21(17):4449-57. PMC: 126195. DOI: 10.1093/emboj/cdf457. View

11.

Cleary J, Lai L, Shaw R, Straatman-Iwanowska A, Donnenberg M, Frankel G . Enteropathogenic Escherichia coli (EPEC) adhesion to intestinal epithelial cells: role of bundle-forming pili (BFP), EspA filaments and intimin. Microbiology (Reading). 2004; 150(Pt 3):527-538. DOI: 10.1099/mic.0.26740-0. View

12.

Gallois A, Klein J, Allen L, Jones B, Nauseef W . Salmonella pathogenicity island 2-encoded type III secretion system mediates exclusion of NADPH oxidase assembly from the phagosomal membrane. J Immunol. 2001; 166(9):5741-8. DOI: 10.4049/jimmunol.166.9.5741. View

13.

Fink S, Cookson B . Pyroptosis and host cell death responses during Salmonella infection. Cell Microbiol. 2007; 9(11):2562-70. DOI: 10.1111/j.1462-5822.2007.01036.x. View

14.

Haraga A, Ohlson M, Miller S . Salmonellae interplay with host cells. Nat Rev Microbiol. 2007; 6(1):53-66. DOI: 10.1038/nrmicro1788. View

15.

Warawa J, Kenny B . Phosphoserine modification of the enteropathogenic Escherichia coli Tir molecule is required to trigger conformational changes in Tir and efficient pedestal elongation. Mol Microbiol. 2002; 42(5):1269-80. DOI: 10.1046/j.1365-2958.2001.02693.x. View

16.

Ramarao N, Clainche C, Izard T, Bourdet-Sicard R, Ageron E, Sansonetti P . Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain. FEBS Lett. 2007; 581(5):853-7. DOI: 10.1016/j.febslet.2007.01.057. View

17.

Heesemann J, Sing A, Trulzsch K . Yersinia's stratagem: targeting innate and adaptive immune defense. Curr Opin Microbiol. 2006; 9(1):55-61. DOI: 10.1016/j.mib.2005.10.018. View

18.

McDonald C, Vacratsis P, Bliska J, Dixon J . The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases. J Biol Chem. 2003; 278(20):18514-23. DOI: 10.1074/jbc.M301226200. View

19.

Luo Y, Frey E, Pfuetzner R, Creagh A, Knoechel D, Haynes C . Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex. Nature. 2000; 405(6790):1073-7. DOI: 10.1038/35016618. View

20.

Torres A, Zhou X, Kaper J . Adherence of diarrheagenic Escherichia coli strains to epithelial cells. Infect Immun. 2004; 73(1):18-29. PMC: 538947. DOI: 10.1128/IAI.73.1.18-29.2005. View