Functional MRI of Tongue Motor Tasks in Patients with Tongue Cancer: Observations Before and After Partial Glossectomy

Overview

Journal Neuroradiology

Specialties Neurology
Radiology

Date 2010 Jul 21

PMID 20644923

Citations 5

Authors

Samantha Haupage

Kyung K Peck

Ryan C Branski

Meier Hsu

Andrei Holodny

Dennis Kraus

Affiliations

Soon will be listed here.

Abstract

Introduction: The current study seeks to provide preliminary data regarding this central, adaptive response during tongue motor tasks utilizing functional magnetic resonance imaging (fMRI) before and after glossectomy.

Methods: Six patients, with confirmed histological diagnoses of oral tongue cancer, underwent fMRI before and 6 months after partial glossectomy. These data were compared to nine healthy controls. All subjects performed three tongue motor tasks during fMRI: tongue tapping (TT), dry swallow (Dry), and wet swallow (Wet).

Results: Following surgery, increased activation was subjectively observed in the superior parietal lobule, supplementary motor area, and anterior cingulate. Region of interest (ROI) analysis of the precentral gyrus confirmed increased cortical activity following surgery. In addition, comparisons between pre-surgical scans and controls suggested the dry swallow task was sensitive to elicit tongue-related activation in the precentral gyrus (p ≤ 0.05).

Conclusions: The adaptive changes in the cortex following partial glossectomy reflect recruitment of the parietal, frontal, and cingulate cortex during tongue motor tasks. In addition, post-operative activation patterns more closely approximated control levels than the pre-operative scans. Furthermore, the dry swallow task appears most specific to elicit tongue-related cortical activity.

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