Recovery of Functional and Structural Age-related Changes in the Rat Primary Auditory Cortex with Operant Training

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2010 Jul 21

PMID 20643928

Citations 105

Authors

Etienne de Villers-Sidani

Loai Alzghoul

Xiaoming Zhou

Kimberly L Simpson

Rick C S Lin

Michael M Merzenich

Affiliations

Soon will be listed here.

Abstract

Cognitive decline is a virtually universal aspect of the aging process. However, its neurophysiological basis remains poorly understood. We describe here more than 20 age-related cortical processing deficits in the primary auditory cortex of aging versus young rats that appear to be strongly contributed to by altered cortical inhibition. Consistent with these changes, we recorded in old rats a decrease in parvalbumin-labeled inhibitory cortical neurons. Furthermore, old rats were slower to master a simple behavior, with learning progressions marked by more false-positive responses. We then examined the effect of intensive auditory training on the primary auditory cortex in these aged rats by using an oddball discrimination task. Following training, we found a nearly complete reversal of the majority of previously observed functional and structural cortical impairments. These findings suggest that age-related cognitive decline is a tightly regulated plastic process, and demonstrate that most of these age-related changes are, by their fundamental nature, reversible.

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