Mast Cell Function is Not Altered by Coronin-1A Deficiency

Overview

Journal J Leukoc Biol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2010 Jul 21

PMID 20643816

Citations 5

Authors

Sanja Arandjelovic

Dilki Wickramarachchi

Saskia Hemmers

Sunamita S Leming

Dwight H Kono

Kerri A Mowen

Affiliations

Soon will be listed here.

Abstract

Coronin-1A is a WD repeat protein family member, highly expressed in all hematopoietic lineages, and acts as a regulator of F-actin dynamics and Ca2+ signaling. In Coro1a(Lmb3) mice results in inactivation of the protein and leads to disease resistance in a model of lupus erythematosus. In Coro1a(-/-) and Coro1a(Lmb3) mice, peripheral T cells exhibit impairments in survival, migration, activation, and Ca2+ flux. In this study, we show that in vitro-differentiated mast cells from Coro1a(Lmb3) mice are viable, developed normally, and are fully functional in assays of degranulation, cytokine secretion, and chemotactic migration, despite increased F-actin levels. In Coro1a(Lmb3) mast cells, Ca2+ flux in response to physiological FcεRI stimulation is unaffected. Finally, Coro1a(Lmb3) mice showed similar in vivo mast cell responses as the WT mice. Coronin-1B and Coronin-1C expression levels were not increased in Coro1a(Lmb3) mast cells but were higher in mast cells than in CD4 T cells or B cells in WT mice. We conclude that Coronin-1A activity is not required for mast cell function.

Citing Articles

Coronins and their role in immunological phenomena.

Tokarz-Deptula B, Malinowska M, Adamiak M, Deptula W Cent Eur J Immunol. 2017; 41(4):435-441.

PMID: 28450807 PMC: 5382889. DOI: 10.5114/ceji.2016.65143.

Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.

Siegmund K, Klepsch V, Hermann-Kleiter N, Baier G J Biol Chem. 2016; 291(42):22086-22092.

PMID: 27566541 PMC: 5063991. DOI: 10.1074/jbc.M116.748012.

On guard: coronin proteins in innate and adaptive immunity.

Pieters J, Muller P, Jayachandran R Nat Rev Immunol. 2013; 13(7):510-8.

PMID: 23765056 DOI: 10.1038/nri3465.

ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor.

Arandjelovic S, McKenney K, Leming S, Mowen K J Immunol. 2012; 189(8):4112-22.

PMID: 22984079 PMC: 3466374. DOI: 10.4049/jimmunol.1201098.

Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b.

Foger N, Jenckel A, Orinska Z, Lee K, Chan A, Bulfone-Paus S J Exp Med. 2011; 208(9):1777-87.

PMID: 21844203 PMC: 3171099. DOI: 10.1084/jem.20101757.

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