Comparisons of Plasma/serum Micronutrients Between Okinawan and Oregonian Elders: a Pilot Study

Overview

Journal J Gerontol A Biol Sci Med Sci

Specialty Geriatrics

Date 2010 Jul 21

PMID 20643702

Citations 8

Authors

Hiroko H Dodge

Yuriko Katsumata

Hidemi Todoriki

Shoutoku Yasura

D Craig Willcox

Gene L Bowman

Bradley Willcox

Scott Leonard

Aaron Clemons

Barry S Oken

Jeffrey A Kaye

Maret G Traber

Affiliations

Soon will be listed here.

Abstract

Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B(12) and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.

Citing Articles

Risk Factors Associated with Cortical Thickness and White Matter Hyperintensities in Dementia Free Okinawan Elderly.

Silbert L, Lahna D, Promjunyakul N, Boespflug E, Ohya Y, Higashiuesato Y J Alzheimers Dis. 2018; 63(1):365-372.

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Associations between Serum Omega-3 Fatty Acid Levels and Cognitive Functions among Community-Dwelling Octogenarians in Okinawa, Japan: The KOCOA Study.

Nishihira J, Tokashiki T, Higashiuesato Y, Willcox D, Mattek N, Shinto L J Alzheimers Dis. 2016; 51(3):857-66.

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Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA Project.

Katsumata Y, Todoriki H, Higashiuesato Y, Yasura S, Ohya Y, Willcox D J Alzheimers Dis. 2012; 34(1):273-9.

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Extending healthy ageing: nutrient sensitive pathway and centenarian population.

Davinelli S, Willcox D, Scapagnini G Immun Ageing. 2012; 9:9.

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Timed up and go test predicts cognitive decline in healthy adults aged 80 and older in Okinawa: Keys to Optimal Cognitive Aging (KOCOA) Project.

Katsumata Y, Todoriki H, Yasura S, Dodge H J Am Geriatr Soc. 2011; 59(11):2188-9.

PMID: 22098046 PMC: 3291095. DOI: 10.1111/j.1532-5415.2011.03645.x.

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