Infant and Childhood Diet and Type 1 Diabetes Risk: Recent Advances and Prospects

Overview

Journal Curr Diab Rep

Publisher Current Science

Specialty Endocrinology

Date 2010 Jul 20

PMID 20640941

Citations 17

Authors

Jill M Norris

Affiliations

Soon will be listed here.

Abstract

Type 1 diabetes is a chronic autoimmune disease characterized by a preclinical period of autoimmunity. It is well accepted that both genetic and environmental factors contribute to disease risk. Given that type 1 diabetes, and its preclinical autoimmunity, appear early in life, infant and childhood diet have been implicated as potential initiating exposures in the etiology of the disease. Several publications in the past year have provided further evidence for existing hypotheses regarding the roles of wheat, cow's milk, omega-3 fatty acids, and the maternal diet during pregnancy. However, inconsistencies in findings between studies suggest the need for collaboration and standardization of study methods to move forward in research in this area. One such example of this is the TEDDY (The Environmental Determinants of Diabetes in the Young) study, which is an international, multicenter birth cohort study with standardized recruitment, dietary collection methodologies, and analytic approaches.

Citing Articles

Pre-Type 1 Diabetes in Adolescents and Teens: Screening, Nutritional Interventions, Beta-Cell Preservation, and Psychosocial Impacts.

Sundheim B, Hirani K, Blaschke M, Lemos J, Mittal R J Clin Med. 2025; 14(2).

PMID: 39860389 PMC: 11765808. DOI: 10.3390/jcm14020383.

Looking back at the TEDDY study: lessons and future directions.

Lernmark A, Agardh D, Akolkar B, Gesualdo P, Hagopian W, Haller M Nat Rev Endocrinol. 2024; 21(3):154-165.

PMID: 39496810 PMC: 11825287. DOI: 10.1038/s41574-024-01045-0.

Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017.

Lawrence J, Divers J, Isom S, Saydah S, Imperatore G, Pihoker C JAMA. 2021; 326(8):717-727.

PMID: 34427600 PMC: 8385600. DOI: 10.1001/jama.2021.11165.

Maternal Dietary Intake of Total Fat, Saturated Fat, and Added Sugar Is Associated with Infant Adiposity and Weight Status at 6 mo of Age.

Nagel E, Jacobs D, Johnson K, Foster L, Duncan K, Kharbanda E J Nutr. 2021; 151(8):2353-2360.

PMID: 33982119 PMC: 8435996. DOI: 10.1093/jn/nxab101.

Lipidomic profiling of plasma free fatty acids in type-1 diabetes highlights specific changes in lipid metabolism.

Sobczak A, Pitt S, Smith T, Ajjan R, Stewart A Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1866(1):158823.

PMID: 33010452 PMC: 7695620. DOI: 10.1016/j.bbalip.2020.158823.

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