Artemisinins and the Biological Basis for the PfATP6/SERCA Hypothesis

Overview

Journal Trends Parasitol

Specialty Parasitology

Date 2010 Jul 20

PMID 20638904

Citations 23

Authors

Sanjeev Krishna

Serena Pulcini

Farrah Fatih

Henry Staines

Affiliations

Soon will be listed here.

Abstract

With the advent of artemisinin resistance, it is timely to revisit the biological basis for the controversial suggestion that this class of antimalarial exerts its activity by inhibiting a calcium ATPase (PfATP6) that is most similar to sarcoplasmic endoplasmic reticulum calcium ATPases (SERCAs). Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere.

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