Specific Fluorogenic Probes for Ozone in Biological and Atmospheric Samples

Overview

Journal Nat Chem

Specialty Chemistry

Date 2010 Jul 17

PMID 20634904

Citations 16

Authors

Amanda L Garner

Claudette M St Croix

Bruce R Pitt

George D Leikauf

Shin Ando

Kazunori Koide

Affiliations

Soon will be listed here.

Abstract

Ozone exposure is a growing global health problem, especially in urban areas. While ozone in the stratosphere protects the earth from harmful ultraviolet light, tropospheric or ground-level ozone is toxic and can damage the respiratory tract. It has recently been shown that ozone may be produced endogenously in inflammation and antibacterial responses of the immune system; however, these results have sparked controversy owing to the use of a non-specific colorimetric probe. Here we report the synthesis of fluorescent molecular probes able to unambiguously detect ozone in both biological and atmospheric samples. Unlike other ozone-detection methods, in which interference from different reactive oxygen species is often a problem, these probes are ozone specific. Such probes will prove useful for the study of ozone in environmental science and biology, and so possibly provide some insight into the role of ozone in cells.

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