G-protein Coupled Receptors in Stem Cell Self-renewal and Differentiation

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2010 Jul 14

PMID 20625855

Citations 14

Authors

Nao R Kobayashi

Susan M Hawes

Jeremy M Crook

Alice Pebay

Affiliations

Soon will be listed here.

Abstract

Stem cells have great potential for understanding early development, treating human disease, tissue trauma and early phase drug discovery. The factors that control the regulation of stem cell survival, proliferation, migration and differentiation are still emerging. Some evidence now exists demonstrating the potent effects of various G-protein coupled receptor (GPCR) ligands on the biology of stem cells. This review aims to give an overview of the current knowledge of the regulation of embryonic and somatic stem cell maintenance and differentiation by GPCR ligands.

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