Angiotensin II Type 1 Receptor-mediated Augmentation of Urinary Excretion of Endogenous Angiotensin II in Val5-angiotensin II-infused Rats

Overview

Journal Hypertension

Date 2010 Jul 14

PMID 20625079

Citations 18

Authors

Weijian Shao

Dale M Seth

L Gabriel Navar

Affiliations

Soon will be listed here.

Abstract

Rats infused chronically with Val(5)-Angiotensin (Ang) II exhibit increased urinary excretion of endogenous Ile(5)-Ang II by the 12th day of infusion, suggesting the stimulation of endogenous Ang II formation by Val(5)-Ang II infusion. The present study determined the time course of increased urinary Ang II excretion and the effects of Ang II type 1 receptor blockade (candesartan, 2 mg/kg per day) on the urinary excretion rates of Ile(5)-Ang II in Val(5)-Ang II-infused (80 ng/min) rats. Ile(5)-Ang II was separated from Val(5)-Ang II by high-performance liquid chromatography and measured by radioimmunoassay. Systolic blood pressure increased progressively (215+/-2 mm Hg) in Val(5)-Ang II-infused rats (n=5), whereas the candesartan-treated group (n=6) remained normotensive (124+/-3 mm Hg). Candesartan treatment significantly increased the level of plasma Ile(5)-Ang II (24.0+/-7.6 versus 156.9+/-24.6 fmol/mL; P<0.01); in contrast, there was a markedly lower intrarenal Ile(5)-Ang II content (357.9+/-76.6 versus 21.1+/-2.8 fmol/g; P<0.01). Urinary Ile(5)-Ang II excretion rates were elevated by day 9 (2185.7+/-283.2 fmol/24 hours) in Val(5)-Ang II-infused rats but not in candesartan-treated rats (740.6+/-110.3 fmol/24 hours). Thus, Ang II type 1 receptor blockade prevents the increase in urinary excretion of endogenous Ang II in rats subjected to chronic Ang II infusion. These data indicate that the increased urinary excretion of endogenous Ang II in Val(5)-Ang II-infused rats is primarily attributed to Ang II type 1 receptor-dependent secretion into and/or de novo formation of Ang II within the tubular lumen.

Citing Articles

Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct.

Lara L, Gonzalez A, Hennrikus M, Prieto M Curr Hypertens Rev. 2022; 18(2):91-100.

PMID: 35170417 PMC: 10132771. DOI: 10.2174/1573402118666220216105357.

Causes and Consequences of the Dysregulated Maternal Renin-Angiotensin System in Preeclampsia.

Lumbers E, Delforce S, Arthurs A, Pringle K Front Endocrinol (Lausanne). 2019; 10:563.

PMID: 31551925 PMC: 6746881. DOI: 10.3389/fendo.2019.00563.

Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice.

Prieto M, Reverte V, Mamenko M, Kuczeriszka M, Veiras L, Rosales C Am J Physiol Renal Physiol. 2017; 313(6):F1243-F1253.

PMID: 28814438 PMC: 5814641. DOI: 10.1152/ajprenal.00152.2017.

Vasopressin/V2 receptor stimulates renin synthesis in the collecting duct.

Gonzalez A, Cifuentes-Araneda F, Ibaceta-Gonzalez C, Gonzalez-Vergara A, Zamora L, Henriquez R Am J Physiol Renal Physiol. 2015; 310(4):F284-93.

PMID: 26608789 PMC: 4888561. DOI: 10.1152/ajprenal.00360.2015.

Role of stimulated intrarenal angiotensinogen in hypertension.

Satou R, Shao W, Navar L Ther Adv Cardiovasc Dis. 2015; 9(4):181-90.

PMID: 25987608 PMC: 4624278. DOI: 10.1177/1753944715585512.

References

Braam B, Mitchell K, Fox J, Navar L . Proximal tubular secretion of angiotensin II in rats. Am J Physiol. 1993; 264(5 Pt 2):F891-8. DOI: 10.1152/ajprenal.1993.264.5.F891. View

Komlosi P, Fuson A, Fintha A, Peti-Peterdi J, Rosivall L, Warnock D . Angiotensin I conversion to angiotensin II stimulates cortical collecting duct sodium transport. Hypertension. 2003; 42(2):195-9. DOI: 10.1161/01.HYP.0000081221.36703.01. View

Fitzsimons J . Angiotensin, thirst, and sodium appetite. Physiol Rev. 1998; 78(3):583-686. DOI: 10.1152/physrev.1998.78.3.583. View

Terada Y, Tomita K, Nonoguchi H, Marumo F . PCR localization of angiotensin II receptor and angiotensinogen mRNAs in rat kidney. Kidney Int. 1993; 43(6):1251-9. DOI: 10.1038/ki.1993.177. View

Voelker J, Cobb S, Bowsher R . Improved HPLC-radioimmunoassay for quantifying angiotensin II in plasma. Clin Chem. 1994; 40(8):1537-43. View

Prieto-Carrasquero M, Harrison-Bernard L, Kobori H, Ozawa Y, Hering-Smith K, Hamm L . Enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. Hypertension. 2004; 44(2):223-9. PMC: 2628717. DOI: 10.1161/01.HYP.0000135678.20725.54. View

Kobori H, Harrison-Bernard L, Navar L . Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production. Kidney Int. 2002; 61(2):579-85. PMC: 2575665. DOI: 10.1046/j.1523-1755.2002.00155.x. View

Gonzalez-Villalobos R, Seth D, Satou R, Horton H, Ohashi N, Miyata K . Intrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice. Am J Physiol Renal Physiol. 2008; 295(3):F772-9. PMC: 2536885. DOI: 10.1152/ajprenal.00019.2008. View

Schunkert H, Ingelfinger J, Jacob H, Jackson B, Bouyounes B, Dzau V . Reciprocal feedback regulation of kidney angiotensinogen and renin mRNA expressions by angiotensin II. Am J Physiol. 1992; 263(5 Pt 1):E863-9. DOI: 10.1152/ajpendo.1992.263.5.E863. View

10.

Mitchell K, Bagatell S, Miller C, Mouton C, Seth D, Mullins J . Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats. J Renin Angiotensin Aldosterone Syst. 2006; 7(2):74-86. DOI: 10.3317/jraas.2006.013. View

11.

Kobori H, Harrison-Bernard L, Navar L . Enhancement of angiotensinogen expression in angiotensin II-dependent hypertension. Hypertension. 2001; 37(5):1329-35. PMC: 2575649. DOI: 10.1161/01.hyp.37.5.1329. View

12.

MOFFETT R, McGowan R, Gross K . Modulation of kidney renin messenger RNA levels during experimentally induced hypertension. Hypertension. 1986; 8(10):874-82. DOI: 10.1161/01.hyp.8.10.874. View

13.

Vincent P, De Vito E . Rat renal and plasma prorenin are activated in vitro by different mechanisms. Hypertension. 1999; 34(3):520-4. DOI: 10.1161/01.hyp.34.3.520. View

14.

Wang C, Chin S, Navar L . Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats. Am J Physiol Renal Physiol. 2000; 279(2):F319-25. DOI: 10.1152/ajprenal.2000.279.2.F319. View

15.

Licea H, Walters M, Navar L . Renal nuclear angiotensin II receptors in normal and hypertensive rats. Acta Physiol Hung. 2002; 89(4):427-38. DOI: 10.1556/APhysiol.89.2002.4.3. View

16.

Chappell M, Brosnihan K, Diz D, Ferrario C . Identification of angiotensin-(1-7) in rat brain. Evidence for differential processing of angiotensin peptides. J Biol Chem. 1989; 264(28):16518-23. View

17.

Anderson K, Peach M . Receptor binding and internalization of a unique biologically active angiotensin II-colloidal gold conjugate: morphological analysis of angiotensin II processing in isolated vascular strips. J Vasc Res. 1994; 31(1):10-7. DOI: 10.1159/000159026. View

18.

El-Dahr S, Dipp S, Guan S, Navar L . Renin, angiotensinogen, and kallikrein gene expression in two-kidney Goldblatt hypertensive rats. Am J Hypertens. 1993; 6(11 Pt 1):914-9. DOI: 10.1093/ajh/6.11.914. View

19.

von Thun A, El-Dahr S, Vari R, Navar L . Modulation of renin-angiotensin and kallikrein gene expression in experimental hypertension. Hypertension. 1994; 23(1 Suppl):I131-6. DOI: 10.1161/01.hyp.23.1_suppl.i131. View

20.

Seikaly M, Arant Jr B, Seney Jr F . Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest. 1990; 86(4):1352-7. PMC: 296870. DOI: 10.1172/JCI114846. View