Epidemiological Investigation of the Association Between Infectious Mononucleosis and Multiple Sclerosis

Overview

Journal Neuroepidemiology

Specialties Neurology
Public Health

Date 1991 Jan 1

PMID 2062419

Citations 26

Authors

C Lindberg

O Andersen

A Vahlne

M DAlton

B Runmarker

Affiliations

Soon will be listed here.

Abstract

By matching a cohort of 494 infectious mononucleosis (IM) cases with a multiple sclerosis (MS) register, 3 MS cases were retrieved. The interval between IM and MS was 12 years. This corresponds to a relative risk of 3.7 for MS to occur subsequent to IM (p = 0.05). This relationship between a manifestation of a relatively late Epstein-Barr virus infection and MS may indicate that a microbiologically shielded environment is important in the pathogenesis of MS.

Citing Articles

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Msheik A, Al Mokdad Z, Hamed F, Assi F, Jibbawi A, Saad J Surg Neurol Int. 2024; 15:355.

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Risk of multiple sclerosis in individuals with infectious mononucleosis: a national population-based cohort study using hospital records in England, 2003-2023.

Goldacre R Mult Scler. 2024; 30(4-5):489-495.

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Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage.

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Alzheimer's disease and multiple sclerosis: a possible connection through the viral demyelinating neurodegenerative trigger (vDENT).

Boukhvalova M, Kastrukoff L, Blanco J Front Aging Neurosci. 2023; 15:1204852.

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Serum IgG levels to Epstein-Barr and measles viruses in patients with multiple sclerosis during natalizumab and interferon beta treatment.

Berg L, Eriksson M, Longhi S, Kockum I, Warnke C, Thomsson E BMJ Neurol Open. 2022; 4(2):e000271.

PMID: 35978722 PMC: 9335035. DOI: 10.1136/bmjno-2022-000271.