Gene Variants Predisposing to SIDS: Current Knowledge

Overview

Journal Forensic Sci Med Pathol

Specialties Forensic Sciences
Pathology

Date 2010 Jul 13

PMID 20623341

Citations 20

Authors

Siri H Opdal

Torleiv O Rognum

Affiliations

Soon will be listed here.

Abstract

Genetic risk factors play a role in sudden unexpected infant death; either as a cause of death, such as in cases with medium-chain acyl-coenzyme A dehydrogenase deficiency and cardiac arrest due to long QT syndrome, or as predisposing factors for sudden infant death syndrome (SIDS). Most likely genetic predisposition to SIDS represent a polygenic inheritance pattern leading to sudden death when combined with other risk factors, such as a vulnerable developmental stage of the central nervous system and/or the immune system, in addition to environmental risk factors, such as a common cold or prone sleeping position. Genes involved in the regulation of the immune system, cardiac function, the serotonergic network and brain function and development have so far emerged as the most important with respect to SIDS. The purpose of the present paper is to survey current knowledge on SIDS and possible genetic contributions.

Citing Articles

The vicious spiral in Sudden Infant Death Syndrome.

Opdal S, Stray-Pedersen A, Eidahl J, Vege A, Ferrante L, Rognum T Front Pediatr. 2025; 13:1487000.

PMID: 40013115 PMC: 11862695. DOI: 10.3389/fped.2025.1487000.

Early Screening for Long QT Syndrome and Cardiac Anomalies in Infants: A Comprehensive Study.

Nosetti L, Zaffanello M, Lombardi C, Gerosa A, Piacentini G, Abramo M Clin Pract. 2024; 14(3):1038-1053.

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Known pathogenic gene variants and new candidates detected in sudden unexpected infant death using whole genome sequencing.

Bard A, Clark L, Cosgun E, Aldinger K, Timms A, Quina L Am J Med Genet A. 2024; 194(11):e63596.

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Risk of Sudden Infant Death Syndrome Among Siblings of Children Who Died of Sudden Infant Death Syndrome in Denmark.

Glinge C, Rossetti S, Oestergaard L, Stampe N, Lynge T, Skals R JAMA Netw Open. 2023; 6(1):e2252724.

PMID: 36696110 PMC: 10187488. DOI: 10.1001/jamanetworkopen.2022.52724.

Genetic variants in eleven central and peripheral chemoreceptor genes in sudden infant death syndrome.

Neubauer J, Forst A, Warth R, Both C, Haas C, Thomas J Pediatr Res. 2022; 92(4):1026-1033.

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