Verisimilitude (or "truthlikeness") As an Alternative to Pro and Cons: Migraine and Cluster Headache Mechanisms
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Calculating verisimilitude (or "truthlikeness") ad modum Popper is a quantitative alternative to the usual pros and cons in migraine and cluster headache mechanisms. The following items were evaluated: dilation of large cranial arteries during migraine; CGRP increase during migraine; migraine as a brain disorder; aura and migraine headache; brain stem activation during migraine; rCBF in migraine without aura; NO and pathophysiology of migraine; neurogenic inflammation and migraine; aura in cluster headache; and hypothalamic activation in cluster headache. It is concluded that verisimilitude calculations can be helpful when judging pathophysiological problems in migraine and cluster headache.
CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.
Russo A, Hay D Physiol Rev. 2022; 103(2):1565-1644.
PMID: 36454715 PMC: 9988538. DOI: 10.1152/physrev.00059.2021.