Temporal Course of Depressive Symptoms During the Development of Alzheimer Disease

Overview

Journal Neurology

Specialty Neurology

Date 2010 Jul 7

PMID 20603481

Citations 21

Authors

R S Wilson

G M Hoganson

K B Rajan

L L Barnes

C F Mendes de Leon

D A Evans

Affiliations

Soon will be listed here.

Abstract

Objective: To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD).

Method: We used data from the Chicago Health and Aging Project, a longitudinal cohort study of risk factors for AD in a geographically defined population of old people. Two subsets were analyzed. In 357 individuals who developed incident AD during the study, self-report of depressive symptoms (Center for Epidemiologic Studies Depression Scale) was obtained at 3-year intervals for a mean of 8 to 9 years. In 340 individuals who agreed to annual data collection, informant report of depressive symptoms (Hamilton Depression Rating Scale) was obtained for a mean of 3 years after a diagnosis of AD (n = 107), mild cognitive impairment (n = 81), or no cognitive impairment (n = 152).

Results: The incident AD group reported a barely perceptible increase in depressive symptoms during 6 to 7 years of observation before the diagnosis (0.04 symptoms per year) and no change during 2 to 3 years of observation after the diagnosis except for a slight decrease in positive affect. In those with annual follow-up, neither AD nor its precursor, mild cognitive impairment, was associated with change in informant report of depressive symptoms during a mean of 3 years of observation.

Conclusion: Depressive symptoms show little change during the development and progression of AD to a moderate level of dementia severity.

Citing Articles

The Interface between Depression and Alzheimer's Disease. A Comprehensive Approach.

Modrego P, de Cerio L, Lobo A Ann Indian Acad Neurol. 2023; 26(4):315-325.

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Late-life depressive symptoms and white matter structural integrity within older Black adults.

Fleischman D, Arfanakis K, Leurgans S, Zhang S, Lamar M, Han S Front Aging Neurosci. 2023; 15:1138568.

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Anxiety and depression in Alzheimer's disease: a systematic review of pathogenetic mechanisms and relation to cognitive decline.

Botto R, Callai N, Cermelli A, Causarano L, Rainero I Neurol Sci. 2022; 43(7):4107-4124.

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A cross-national study of depression in preclinical dementia: A COSMIC collaboration study.

Carles S, Carriere I, Reppermund S, Davin A, Guaita A, Vaccaro R Alzheimers Dement. 2020; 16(11):1544-1552.

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Norton J, Carriere I, Peres K, Gabelle A, Berr C, Ritchie K Transl Psychiatry. 2019; 9(1):291.

PMID: 31712553 PMC: 6848073. DOI: 10.1038/s41398-019-0620-5.

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