Fascin over Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas: a Study of 47 Cases

Overview

Journal Head Neck Pathol

Specialties Oncology
Pathology

Date 2010 Jul 3

PMID 20596974

Citations 9

Authors

Hope H Wu

Samiah Zafar

Youming Huan

Herman Yee

Luis Chiriboga

Beverly Y Wang

Affiliations

Soon will be listed here.

Abstract

Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.

Citing Articles

IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma.

Hakim S, Abd Raboh N, Shash L Anal Cell Pathol (Amst). 2021; 2021:6639834.

PMID: 33680717 PMC: 7904363. DOI: 10.1155/2021/6639834.

Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma.

Long C, Jabarin B, Harvey A, Ham J, Javer A, Janjua A J Otolaryngol Head Neck Surg. 2020; 49(1):25.

PMID: 32354352 PMC: 7193386. DOI: 10.1186/s40463-020-00420-x.

Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing.

Yasukawa S, Kano S, Hatakeyama H, Nakamaru Y, Takagi D, Mizumachi T Int J Clin Oncol. 2018; 23(5):835-843.

PMID: 29779136 DOI: 10.1007/s10147-018-1296-1.

Advances in recurrence and malignant transformation of sinonasal inverted papillomas.

Sun Q, An L, Zheng J, Zhu D Oncol Lett. 2017; 13(6):4585-4592.

PMID: 28599459 PMC: 5453000. DOI: 10.3892/ol.2017.6089.

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review.

Re M, Gioacchini F, Bajraktari A, Tomasetti M, Kaleci S, Rubini C Eur Arch Otorhinolaryngol. 2017; 274(8):2991-3000.

PMID: 28432463 DOI: 10.1007/s00405-017-4571-2.

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