Lack of Active Onchocerca Volvulus Transmission in the Northern Chiapas Focus of Mexico

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2010 Jul 3

PMID 20595471

Citations 14

Authors

Mario A Rodriguez-Perez

Thomas R Unnasch

Alfredo Dominguez-Vazquez

Alba L Morales-Castro

Frank Richards Jr

Graciela P Pena-Flores

Maria Eugenia Orozco-Algarra

Gibert Prado-Velasco

Affiliations

Soon will be listed here.

Abstract

The northern Chiapas onchocerciasis focus has undergone 11 years of ivermectin mass treatment. No evidence of microfilariae in the cornea and/or anterior chamber of the eye or in skin snips was seen in residents examined in 2006 in two sentinel communities (upper limit of the 95% confidence interval [UL 95% CI] = 0.5% and 0.3%, respectively). In children 10 and under, 0 of 305 were found to harbor antibodies to Ov16, a marker of parasite exposure; 0 of 4,400 Simulium ochraceum s.l. collected in 2005 contained parasite DNA, giving an UL 95% CI for the infective rate of 0.9/2,000, and an UL 95% CI of the seasonal transmission potential of 1.2 L3/person. These data, assumed to be representative of the focus as a whole, suggest that there is no ongoing transmission of Onchocerca volvulus in the northern Chiapas focus. Community-wide treatments with ivermectin were halted in 2008, and a post-treatment surveillance phase was initiated.

Citing Articles

Changes in Anti-OV-16 IgG4 Responses to Onchocerciasis after Elimination of Transmission in the Central Endemic Zone of Guatemala.

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Criteria for selecting sentinel unit locations in a surveillance system for vector-borne disease: A decision tool.

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Historical Review and Cost-Effectiveness Assessment of the Programs to Eliminate Onchocerciasis and Trachoma in Mexico.

Fernandez-Santos N, Prado-Velasco F, Damian-Gonzalez D, Unnasch T, Rodriguez-Perez M Res Rep Trop Med. 2021; 12:235-245.

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Predictive Value of Ov16 Antibody Prevalence in Different Subpopulations for Elimination of African Onchocerciasis.

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Operational Performance of the "OEPA" Ov16 ELISA Serological Assay in Mapping, Guiding Decisions to Stop Mass Drug Administration, and Posttreatment Surveillance Surveys.

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