Multifunctional Magnetic Nanoparticles for Medical Imaging Applications

Overview

Journal J Mater Chem

Publisher Royal Society of Chemistry

Date 2010 Jul 2

PMID 20593005

Citations 47

Authors

Chen Fang

Miqin Zhang

Affiliations

Soon will be listed here.

Abstract

Magnetic nanoparticles (MNPs) have attracted enormous research attention due to their unique magnetic properties that enable the detection by the non-invasive medical imaging modality-magnetic resonance imaging (MRI). By incorporating advanced features, such as specific targeting, multimodality, therapeutic delivery, the detectability and applicability of MNPs have been dramatically expanded. A delicate design on structure, composition and surface chemistry is essential to achieving desired properties in MNP systems, such as high imaging contrast and chemical stability, non-fouling surface, target specificity and/or multimodality. This article presents the design fundamentals on the development of MNP systems, from discussion of material selection for nanoparticle cores and coatings, strategies for chemical synthesis and surface modification and their merits and limitations, to conjugation of special biomolecules for intended functions, and reviews the recent advances in the field.

Citing Articles

Exploring Innovative Approaches in Type-2 Diabetes Management: A Comprehensive Review on Nano-carriers and Transdermal Drug Delivery.

Chauhan N, Kumar M, Kumar K, Chopra S, Bhatia A Curr Pharm Des. 2024; 30(22):1725-1745.

PMID: 38847167 DOI: 10.2174/0113816128313325240513113840.

Functional Diversity in Radiolabeled Nanoceramics and Related Biomaterials for the Multimodal Imaging of Tumors.

Calatayud D, Lledos M, Casarsa F, Pascu S ACS Bio Med Chem Au. 2023; 3(5):389-417.

PMID: 37876497 PMC: 10591303. DOI: 10.1021/acsbiomedchemau.3c00021.

Carbon Coated Iron-Cobalt Nanoparticles for Magnetic Particle Imaging.

Kumar R, Huda M, Habib A, Nafiujjaman M, Woo H, Kim T ACS Appl Bio Mater. 2023; 6(8):3257-3265.

PMID: 37554053 PMC: 10787597. DOI: 10.1021/acsabm.3c00354.

Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications.

Nowak-Jary J, Machnicka B J Nanobiotechnology. 2022; 20(1):305.

PMID: 35761279 PMC: 9235206. DOI: 10.1186/s12951-022-01510-w.

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application.

Kush P, Kumar P, Singh R, Kaushik A Asian J Pharm Sci. 2022; 16(6):704-737.

PMID: 35027950 PMC: 8737424. DOI: 10.1016/j.ajps.2021.05.005.

References

Park J, An K, Hwang Y, Park J, Noh H, Kim J . Ultra-large-scale syntheses of monodisperse nanocrystals. Nat Mater. 2004; 3(12):891-5. DOI: 10.1038/nmat1251. View

Zhang Y, Sun C, Kohler N, Zhang M . Self-assembled coatings on individual monodisperse magnetite nanoparticles for efficient intracellular uptake. Biomed Microdevices. 2004; 6(1):33-40. DOI: 10.1023/b:bmmd.0000013363.77466.63. View

Caravan P, Ellison J, McMurry T, Lauffer R . Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications. Chem Rev. 2001; 99(9):2293-352. DOI: 10.1021/cr980440x. View

Kohler N, Fryxell G, Zhang M . A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents. J Am Chem Soc. 2004; 126(23):7206-11. DOI: 10.1021/ja049195r. View

Seo W, Lee J, Sun X, Suzuki Y, Mann D, Liu Z . FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents. Nat Mater. 2006; 5(12):971-6. DOI: 10.1038/nmat1775. View

Cao Y . Synthesis of square gadolinium-oxide nanoplates. J Am Chem Soc. 2004; 126(24):7456-7. DOI: 10.1021/ja0481676. View

Rudin M, Weissleder R . Molecular imaging in drug discovery and development. Nat Rev Drug Discov. 2003; 2(2):123-31. DOI: 10.1038/nrd1007. View

Hifumi H, Yamaoka S, Tanimoto A, Citterio D, Suzuki K . Gadolinium-based hybrid nanoparticles as a positive MR contrast agent. J Am Chem Soc. 2006; 128(47):15090-1. DOI: 10.1021/ja066442d. View

Massoud T, Gambhir S . Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 2003; 17(5):545-80. DOI: 10.1101/gad.1047403. View

10.

Veiseh O, Gunn J, Zhang M . Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev. 2009; 62(3):284-304. PMC: 2827645. DOI: 10.1016/j.addr.2009.11.002. View

11.

Lu A, Salabas E, Schuth F . Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed Engl. 2007; 46(8):1222-44. DOI: 10.1002/anie.200602866. View

12.

Peer D, Karp J, Hong S, Farokhzad O, Margalit R, Langer R . Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2008; 2(12):751-60. DOI: 10.1038/nnano.2007.387. View

13.

Quarta A, Di Corato R, Manna L, Ragusa A, Pellegrino T . Fluorescent-magnetic hybrid nanostructures: preparation, properties, and applications in biology. IEEE Trans Nanobioscience. 2008; 6(4):298-308. DOI: 10.1109/tnb.2007.908989. View

14.

Bulte J, Kraitchman D . Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed. 2004; 17(7):484-99. DOI: 10.1002/nbm.924. View

15.

Choi S, Na H, Park Y, An K, Kwon S, Jang Y . Simple and generalized synthesis of oxide-metal heterostructured nanoparticles and their applications in multimodal biomedical probes. J Am Chem Soc. 2008; 130(46):15573-80. DOI: 10.1021/ja805311x. View

16.

Wang Y, Hussain S, Krestin G . Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur Radiol. 2001; 11(11):2319-31. DOI: 10.1007/s003300100908. View

17.

Montet X, Funovics M, Montet-Abou K, Weissleder R, Josephson L . Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem. 2006; 49(20):6087-93. DOI: 10.1021/jm060515m. View

18.

Sun S, Zeng H, Robinson D, Raoux S, Rice P, Wang S . Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles. J Am Chem Soc. 2004; 126(1):273-9. DOI: 10.1021/ja0380852. View

19.

Cai W, Chen X . Nanoplatforms for targeted molecular imaging in living subjects. Small. 2007; 3(11):1840-54. DOI: 10.1002/smll.200700351. View

20.

Shin J, Anisur R, Ko M, Im G, Lee J, Lee I . Hollow manganese oxide nanoparticles as multifunctional agents for magnetic resonance imaging and drug delivery. Angew Chem Int Ed Engl. 2008; 48(2):321-4. DOI: 10.1002/anie.200802323. View