Does Improvement Management of Atopic Dermatitis Influence the Appearance of Respiratory Allergic Diseases? A Follow-up Study

Overview

Journal Clin Mol Allergy

Publisher Biomed Central

Specialty Allergy & Immunology

Date 2010 Jul 2

PMID 20591145

Citations 9

Authors

Giampaolo Ricci

Annalisa Patrizi

Arianna Giannetti

Arianna Dondi

Barbara Bendandi

Massimo Masi

Affiliations

Soon will be listed here.

Abstract

Background: Atopic dermatitis (AD) is often the prelude to allergic diseases. The aim of this study was 1) to evaluate if an integrated management regime could bring about a change in the evolution of the disease in comparison to the results of a previous study; 2) to determine whether the refinement of allergic investigations allowed to identify more promptly the risk factors of evolution into respiratory allergic diseases.

Methods: The study included 176 children affected by AD and previously evaluated between 1993 and 2002 at the age of 9-16 months, who underwent a telephonic interview by means of a semi-structured, pre-formed questionnaire after a mean follow-up time of 8 years. According to the SCORAD, at first evaluation children had mild AD in 23% of cases, moderate in 62%, severe in 15%.

Results: AD disappeared in 92 cases (52%), asthma appeared in 30 (17%) and rhinoconjunctivitis in 48 (27%). The factors significantly related to the appearance of asthma were: sensitization to food allergens with sIgE > 2 KU/L (cow's milk and hen's egg; P < 0.05); to inhalant allergens with sIgE > 0.35 KU/L (P < 0.05). Logistic regression analysis showed that inhalant sensitization was positively related to the occurrence of asthma (OR = 4.219). While AD showed similar rates of disappearance to those of our previous study, the incidence of asthma was reduced, at the same follow-up time, from 29% to 15% (P = 0.002), and the incidence of rhinoconjunctivitis from 35% to 24% (P = 0.02).

Conclusion: Comparing the results with those of the previous study, integrated management of AD does not seem to influence its natural course. Nevertheless, the decrease in the percentage of children evolving towards respiratory allergic disease stresses the importance of early diagnosis and improvement management carried out by specialist centers. The presence of allergic sensitization at one year of age might predict the development of respiratory allergy.

Citing Articles

Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review.

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Evaluating the Longitudinal Course of Atopic Dermatitis: Implications for Clinical Practice.

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Filaggrin Loss-of-Function Mutations Are Risk Factors for Severe Food Allergy in Children with Atopic Dermatitis.

Astolfi A, Cipriani F, Messelodi D, De Luca M, Indio V, Di Chiara C J Clin Med. 2021; 10(2).

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Persistence of atopic dermatitis (AD): A systematic review and meta-analysis.

Kim J, Chao L, Simpson E, Silverberg J J Am Acad Dermatol. 2016; 75(4):681-687.e11.

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The severity of atopic dermatitis evaluated with the SCORAD index and the occurrence of bronchial asthma and rhinitis, and the duration of atopic dermatitis.

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PMID: 27103554 PMC: 4837137. DOI: 10.2500/ar.2016.7.0144.

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