Luteolin Suppresses Growth and Migration of Human Lung Cancer Cells

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2010 Jul 1

PMID 20589534

Citations 11

Authors

Yunxue Zhao

Guotao Yang

Dongmei Ren

Xiumei Zhang

Qiuwei Yin

Xuefei Sun

Affiliations

Soon will be listed here.

Abstract

Luteolin, 3',4',5,7-tetrahydroxyflavone, has been shown to possess antioxidant, anti-inflammation and anti-cancer properties. However, its role in lung cancer remains poorly understood. Here we examined the anti-tumorigenic role of luteolin in a commonly used lung cancer cell line. Luteolin inhibited the growth of A549 cells by inducing G1 phase cell cycle arrest and apoptosis. Furthermore, stress fiber assembly and cell migration in A549 cells was markedly suppressed by luteolin.

Citing Articles

Phytochemical Study and In Vitro Antioxidant Activity of Along with Antitumor Activity of the Isolated -Tiliroside and Luteolin 4'--β-Xyloside.

Bertella A, Smadi A, Benhabrou H, Salvador D, Wrona M, Oliveira H Molecules. 2025; 29(24.

PMID: 39770024 PMC: 11678426. DOI: 10.3390/molecules29245935.

Network pharmacology study to explore the multiple molecular mechanism of SH003 in the treatment of non-small cell lung cancer.

Lee K, Choi Y, Lim H, Cho K, Kang N, Ko S BMC Complement Med Ther. 2024; 24(1):70.

PMID: 38303001 PMC: 10832243. DOI: 10.1186/s12906-024-04347-y.

Hydroalcoholic Extract as a Hypoallergenic Antimicrobial Substitute of Natural Origin for Commonly Used Preservatives in Cosmetic Emulsions.

Langova D, Cordoba M, Sorrechia R, Hoova J, Svoboda Z, Mikulikova R Plants (Basel). 2023; 12(10).

PMID: 37653944 PMC: 10222649. DOI: 10.3390/plants12102027.

Luteolin: a flavonoid with a multifaceted anticancer potential.

Prasher P, Sharma M, Singh S, Gulati M, Chellappan D, Zacconi F Cancer Cell Int. 2022; 22(1):386.

PMID: 36482329 PMC: 9730645. DOI: 10.1186/s12935-022-02808-3.

The Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents.

Mohi-Ud-Din R, Mir R, Wani T, Alsharif K, Alam W, Albrakati A Molecules. 2022; 27(8).

PMID: 35458669 PMC: 9031790. DOI: 10.3390/molecules27082471.

References

Leung H, Wu C, Lin C, Lee H . Luteolin induced DNA damage leading to human lung squamous carcinoma CH27 cell apoptosis. Eur J Pharmacol. 2005; 508(1-3):77-83. DOI: 10.1016/j.ejphar.2004.12.032. View

Hunter K, Crawford N, Alsarraj J . Mechanisms of metastasis. Breast Cancer Res. 2008; 10 Suppl 1:S2. PMC: 2605099. DOI: 10.1186/bcr1988. View

Vignjevic D, Montagnac G . Reorganisation of the dendritic actin network during cancer cell migration and invasion. Semin Cancer Biol. 2007; 18(1):12-22. DOI: 10.1016/j.semcancer.2007.08.001. View

Jiang G, Zhong X, Cui Y, Liu W, Tai S, Wang Z . IL-6/STAT3/TFF3 signaling regulates human biliary epithelial cell migration and wound healing in vitro. Mol Biol Rep. 2010; 37(8):3813-8. DOI: 10.1007/s11033-010-0036-z. View

Zhao Y, Zhou Y, OBoyle K, Murphy P . Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis. Bioorg Med Chem. 2008; 16(12):6333-7. DOI: 10.1016/j.bmc.2008.05.012. View

Zhao Y, Li J, Xing Y, Wang J, Lu C, Xin X . N-acetylglucosaminyltransferase V mediates cell migration and invasion of mouse mammary tumor cells 4TO7 via RhoA and Rac1 signaling pathway. Mol Cell Biochem. 2007; 309(1-2):199-208. DOI: 10.1007/s11010-007-9656-6. View

Zhang L, Huang H, Wu K, Wang M, Wu B . Impact of BTG2 expression on proliferation and invasion of gastric cancer cells in vitro. Mol Biol Rep. 2009; 37(6):2579-86. DOI: 10.1007/s11033-009-9777-y. View

Shi L, Zhao M, Luo Q, Ma Y, Zhong J, Yuan X . Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. Mol Biol Rep. 2009; 37(5):2189-98. DOI: 10.1007/s11033-009-9701-5. View

Ren K, Jin H, Bian C, He H, Liu X, Zhang S . MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway. J Biol Chem. 2008; 283(51):35598-605. DOI: 10.1074/jbc.M802253200. View

10.

Hong L, Sun H, Lv X, Yang D, Zhang J, Shi Y . Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro. Mol Biol Rep. 2009; 37(5):2285-93. DOI: 10.1007/s11033-009-9721-1. View

11.

Zhou Y, Zhao Y, O Boyle K, Murphy P . Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles. Bioorg Med Chem Lett. 2008; 18(3):954-8. DOI: 10.1016/j.bmcl.2007.12.034. View

12.

Ren D, Qu Z, Wang X, Shi J, Lou H . Simultaneous determination of nine major active compounds in Dracocephalum rupestre by HPLC. J Pharm Biomed Anal. 2008; 48(5):1441-5. DOI: 10.1016/j.jpba.2008.09.013. View

13.

Tait J . Imaging of apoptosis. J Nucl Med. 2008; 49(10):1573-6. DOI: 10.2967/jnumed.108.052803. View

14.

Lee J, Kim I . Leukotactin-1/CCL15 induces cell migration and differentiation of human eosinophilic leukemia EoL-1 cells through PKCdelta activation. Mol Biol Rep. 2009; 37(5):2149-56. DOI: 10.1007/s11033-009-9687-z. View

15.

Palm D, Lang K, Brandt B, Zaenker K, Entschladen F . In vitro and in vivo imaging of cell migration: two interdepending methods to unravel metastasis formation. Semin Cancer Biol. 2005; 15(5):396-404. DOI: 10.1016/j.semcancer.2005.06.008. View

16.

Wang Z, Tang X, Li Y, Leu C, Guo L, Zheng X . 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. Eur J Pharmacol. 2008; 588(1):9-17. DOI: 10.1016/j.ejphar.2008.03.045. View

17.

Zhang Q, Zhao X, Wang Z . Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008; 46(6):2042-53. DOI: 10.1016/j.fct.2008.01.049. View

18.

Lin Y, Shi R, Wang X, Shen H . Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets. 2008; 8(7):634-46. PMC: 2615542. DOI: 10.2174/156800908786241050. View

19.

Casagrande F, Darbon J . Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001; 61(10):1205-15. DOI: 10.1016/s0006-2952(01)00583-4. View

20.

Wang S, Wang K, Xin Y, Lv D . Maggot excretions/secretions induces human microvascular endothelial cell migration through AKT1. Mol Biol Rep. 2009; 37(6):2719-25. DOI: 10.1007/s11033-009-9806-x. View