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Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection

Overview
Journal Diabetes Care
Specialty Endocrinology
Date 2010 Jul 1
PMID 20587722
Citations 170
Authors
Robert Allard
Pascale Leclerc
Claude Tremblay
Terry-Nan Tannenbaum
Affiliations
Soon will be listed here.
Abstract

Objective: To confirm the existence of an increased risk of complications from influenza A (H1N1)p among patients with diabetes.

Research Design And Methods: Using data from an enhanced influenza surveillance project in Montreal, Canada, and age/sex-specific population estimates of diabetes prevalence, we estimated the risk of hospitalization among persons with diabetes. Comparing hospitalized patients admitted or not to an intensive care unit (ICU), we estimated the risk of ICU admission associated with diabetes, controlling for other patient characteristics.

Results: Among 239 hospitalized patients with PCR-confirmed influenza A (H1N1)p, 162 (68%) were interviewed, of whom 22 had diabetes, when 7.1 were expected (prevalence ratio 3.10 [95% CI 2.04-4.71]). The odds ratio for ICU admission was 4.29 (95% CI 1.29-14.3) among hospitalized patients with diabetes compared to those without.

Conclusions: Diabetes triples the risk of hospitalization after influenza A (H1N1)p and quadruples the risk of ICU admission once hospitalized.

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