Mild Traumatic Brain Injury: a Risk Factor for Neurodegeneration

Overview

Journal Alzheimers Res Ther

Date 2010 Jul 1

PMID 20587081

Citations 81

Authors

Brandon E Gavett

Robert A Stern

Robert C Cantu

Christopher J Nowinski

Ann C McKee

Affiliations

Soon will be listed here.

Abstract

Recently, it has become clear that head trauma can lead to a progressive neurodegeneration known as chronic traumatic encephalopathy. Although the medical literature also implicates head trauma as a risk factor for Alzheimer's disease, these findings are predominantly based on clinical diagnostic criteria that lack specificity. The dementia that follows head injuries or repetitive mild trauma may be caused by chronic traumatic encephalopathy, alone or in conjunction with other neurodegenerations (for example, Alzheimer's disease). Prospective longitudinal studies of head-injured individuals, with neuropathological verification, will not only improve understanding of head trauma as a risk factor for dementia but will also enhance treatment and prevention of a variety of neurodegenerative diseases.

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