Electrical Stimulation Compared with Tolterodine for Treatment of Urge/urge Incontinence Amongst Women--a Randomized Controlled Trial

Overview

Journal Int Urogynecol J

Publisher Springer

Specialties Gynecology & Obstetrics
Urology

Date 2010 Jun 30

PMID 20585755

Citations 7

Authors

Karin Franzen

Jan-Erik Johansson

Inger Lauridsen

Jill Canelid

Bengt Heiwall

Kerstin Nilsson

Affiliations

Soon will be listed here.

Abstract

Introduction And Hypothesis: Few randomized controlled trials have compared electrical stimulation treatment with drug therapy. Our hypothesis was that electrical stimulation treatment in women with urgency/urge incontinence would be more efficient compared to drug treatment.

Methods: Women ≥18 years of age with urgency/urge incontinence were randomized to receive either ten electrical stimulation treatments vaginally and transanally over a period of 5-7 weeks or tolterodine 4 mg orally once daily.

Results: Sixty-one women completed the study. There was no significant difference between the two treatment groups in micturition rate from baseline to 6 months, mean difference, -0.40 (95% confidence interval (CI), -1.61 to 0.82), but a clearly significant difference within each group for electrical stimulation, -2.8 (95% CI, -3.7 to -1.9), and for tolterodine, -3.2 (95% CI, -4.1 to -2.4).

Conclusions: Both treatments reduced the number of micturitions, but electrical stimulation was not found to be superior to tolterodine.

Citing Articles

Effects of external neuromuscular electrical stimulation in women with urgency urinary incontinence: a randomized sham-controlled study.

Kurt T, Yilmaz B, Toprak Celenay S World J Urol. 2024; 42(1):423.

PMID: 39033475 PMC: 11271381. DOI: 10.1007/s00345-024-05126-7.

Technologies for Evaluation of Pelvic Floor Functionality: A Systematic Review.

Forstl N, Adler I, Suss F, Dendorfer S Sensors (Basel). 2024; 24(12).

PMID: 38931784 PMC: 11207910. DOI: 10.3390/s24124001.

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults.

Stoniute A, Madhuvrata P, Still M, Barron-Millar E, Nabi G, Omar M Cochrane Database Syst Rev. 2023; 5:CD003781.

PMID: 37160401 PMC: 10167789. DOI: 10.1002/14651858.CD003781.pub3.

Conservative interventions for treating urinary incontinence in women: an Overview of Cochrane systematic reviews.

Todhunter-Brown A, Hazelton C, Campbell P, Elders A, Hagen S, McClurg D Cochrane Database Syst Rev. 2022; 9:CD012337.

PMID: 36053030 PMC: 9437962. DOI: 10.1002/14651858.CD012337.pub2.

Urinary Incontinence in Women: Modern Methods of Physiotherapy as a Support for Surgical Treatment or Independent Therapy.

Mazur-Bialy A, Kolomanska-Bogucka D, Nowakowski C, Tim S J Clin Med. 2020; 9(4).

PMID: 32340194 PMC: 7230757. DOI: 10.3390/jcm9041211.

References

Chapple C, Khullar V, Gabriel Z, Muston D, Bitoun C, Weinstein D . The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis. Eur Urol. 2008; 54(3):543-62. DOI: 10.1016/j.eururo.2008.06.047. View

Smith 3rd J . Intravaginal stimulation randomized trial. J Urol. 1996; 155(1):127-30. View

Caputo R, Benson J, McClellan E . Intravaginal maximal electrical stimulation in the treatment of urinary incontinence. J Reprod Med. 1993; 38(9):667-71. View

Nakamura M, Sakurai T, Sugao H, Sonoda T . Maximum electrical stimulation for urge incontinence. Urol Int. 1987; 42(4):285-7. DOI: 10.1159/000281957. View

Brubaker L, Benson J, Bent A, Clark A, Shott S . Transvaginal electrical stimulation for female urinary incontinence. Am J Obstet Gynecol. 1997; 177(3):536-40. DOI: 10.1016/s0002-9378(97)70142-x. View

Reese P, Pleil A, Okano G, Kelleher C . Multinational study of reliability and validity of the King's Health Questionnaire in patients with overactive bladder. Qual Life Res. 2003; 12(4):427-42. DOI: 10.1023/a:1023422208910. View

Crandall C . Tolterodine: a clinical review. J Womens Health Gend Based Med. 2001; 10(8):735-43. DOI: 10.1089/15246090152636488. View

Van Kerrebroeck P, Amarenco G, Thuroff J, Madersbacher H, Lock M, Messelink E . Dose-ranging study of tolterodine in patients with detrusor hyperreflexia. Neurourol Urodyn. 1998; 17(5):499-512. DOI: 10.1002/(sici)1520-6777(1998)17:5<499::aid-nau6>3.0.co;2-8. View

Arruda R, Castro R, Sousa G, Sartori M, Baracat E, Girao M . Prospective randomized comparison of oxybutynin, functional electrostimulation, and pelvic floor training for treatment of detrusor overactivity in women. Int Urogynecol J Pelvic Floor Dysfunct. 2008; 19(8):1055-61. DOI: 10.1007/s00192-008-0586-y. View

10.

Fossberg E, Sorensen S, Ruutu M, Bakke A, Stien R, Henriksson L . Maximal electrical stimulation in the treatment of unstable detrusor and urge incontinence. Eur Urol. 1990; 18(2):120-3. DOI: 10.1159/000463887. View

11.

Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U . The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn. 2002; 21(2):167-78. DOI: 10.1002/nau.10052. View

12.

Norton P, Brubaker L . Urinary incontinence in women. Lancet. 2006; 367(9504):57-67. DOI: 10.1016/S0140-6736(06)67925-7. View

13.

Berghmans L, Hendriks H, de Bie R, van Waalwijk van Doorn E, Bo K, Van Kerrebroeck P . Conservative treatment of urge urinary incontinence in women: a systematic review of randomized clinical trials. BJU Int. 2000; 85(3):254-63. DOI: 10.1046/j.1464-410x.2000.00434.x. View

14.

Geirsson G, Fall M . Maximal functional electrical stimulation in routine practice. Neurourol Urodyn. 1997; 16(6):559-65. DOI: 10.1002/(sici)1520-6777(1997)16:6<559::aid-nau6>3.0.co;2-d. View

15.

Tincello D, Kenyon S, Slack M, Toozs-Hobson P, Mayne C, Jones D . Colposuspension or TVT with anterior repair for urinary incontinence and prolapse: results of and lessons from a pilot randomised patient-preference study (CARPET 1). BJOG. 2009; 116(13):1809-14. DOI: 10.1111/j.1471-0528.2009.02355.x. View

16.

Hunskaar S, Arnold E, Burgio K, Diokno A, Herzog A, Mallett V . Epidemiology and natural history of urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2000; 11(5):301-19. DOI: 10.1007/s001920070021. View

17.

Freeman R . How urgent is urgency? A review of current methods of assessment. Int Urogynecol J Pelvic Floor Dysfunct. 2005; 16(2):93-5. DOI: 10.1007/s00192-004-1253-6. View

18.

Nabi G, Cody J, Ellis G, Herbison P, Hay-Smith J . Anticholinergic drugs versus placebo for overactive bladder syndrome in adults. Cochrane Database Syst Rev. 2006; (4):CD003781. PMC: 8729219. DOI: 10.1002/14651858.CD003781.pub2. View

19.

Ohlsson B, Fall M . Effects of external and direct pudendal nerve maximal electrical stimulation in the treatment of the uninhibited overactive bladder. Br J Urol. 1989; 64(4):374-80. DOI: 10.1111/j.1464-410x.1989.tb06046.x. View

20.

Eriksen B, Bergmann S, MJOLNEROD O . Effect of anal electrostimulation with the 'Incontan' device in women with urinary incontinence. Br J Obstet Gynaecol. 1987; 94(2):147-56. DOI: 10.1111/j.1471-0528.1987.tb02342.x. View