F-BAR Domain Proteins: Families and Function

Overview

Journal Commun Integr Biol

Specialty Biology

Date 2010 Jun 30

PMID 20585502

Citations 14

Authors

Sohail Ahmed

Wenyu Bu

Raphael Tze Chuen Lee

Sebastian Maurer-Stroh

Wah Ing Goh

Affiliations

Soon will be listed here.

Abstract

The F-BAR domain is emerging as an important player in membrane remodeling pathways. F-BAR domain proteins couple membrane remodeling with actin dynamics associated with endocytic pathways and filopodium formation. Here, we provide a comprehensive analysis of F-BAR domain proteins in terms of their evolutionary relationships and protein function. F-BAR domain containing proteins can be categorized into five subfamilies based on their phylogeny which is consistent with the additional protein domains they possess, for example, RhoGAP domains, Cdc42 binding sites, SH3 domains and tyrosine kinase domains. We derive a protein-protein interaction network suggesting that dynamin1/2, N-WASP, Huntingtin, intersectin and Cdc42 are central nodes influencing F-BAR domain protein function.

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