Genome-wide Association Studies of Cancer

Overview

Journal J Clin Oncol

Specialty Oncology

Date 2010 Jun 30

PMID 20585100

Citations 92

Authors

Zsofia K Stadler

Peter Thom

Mark E Robson

Jeffrey N Weitzel

Noah D Kauff

Karen E Hurley

Vincent Devlin

Bert Gold

Robert J Klein

Kenneth Offit

Affiliations

Soon will be listed here.

Abstract

Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies. Increased knowledge about the human genome and advances in genotyping technology have made possible genome-wide association studies (GWAS) of human diseases. These studies have identified many important regions of genetic variation associated with an increased risk for human traits and diseases including cancer. Understanding the principles, major findings, and limitations of GWAS is becoming increasingly important for oncologists as dissemination of genomic risk tests directly to consumers is already occurring through commercial companies. GWAS have contributed to our understanding of the genetic basis of cancer and will shed light on biologic pathways and possible new strategies for targeted prevention. To date, however, the clinical utility of GWAS-derived risk markers remains limited.

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