8q24 Sequence Variants in Relation to Prostate Cancer Risk Among Men of African Descent: a Case-control Study

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2010 Jun 30

PMID 20584312

Citations 13

Authors

Marnita L Benford

Tiva T VanCleave

Nicole A Lavender

Rick A Kittles

LaCreis R Kidd

Affiliations

Soon will be listed here.

Abstract

Background: Human chromosome 8q24 has been implicated in prostate tumorigenesis.

Methods: Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR).

Results: Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes.

Conclusions: Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.

Citing Articles

Cumulative evidence of relationships between multiple variants in 8q24 region and cancer incidence.

Tong Y, Tang Y, Li S, Zhao F, Ying J, Qu Y Medicine (Baltimore). 2020; 99(26):e20716.

PMID: 32590746 PMC: 7328976. DOI: 10.1097/MD.0000000000020716.

Cumulative Evidence for Relationships Between 8q24 Variants and Prostate Cancer.

Tong Y, Yu T, Li S, Zhao F, Ying J, Qu Y Front Physiol. 2018; 9:915.

PMID: 30061842 PMC: 6055007. DOI: 10.3389/fphys.2018.00915.

Association between 8q24 Gene Polymorphisms and the Risk of Prostate Cancer: A Systematic Review and Meta-Analysis.

Li R, Qin Z, Tang J, Han P, Xing Q, Wang F J Cancer. 2017; 8(16):3198-3211.

PMID: 29158792 PMC: 5665036. DOI: 10.7150/jca.20456.

Association of three 8q24 polymorphisms with prostate cancer susceptibility: evidence from a meta-analysis with 50,854 subjects.

Li Q, Liu X, Hua R, Wang F, An H, Zhang W Sci Rep. 2015; 5:12069.

PMID: 26159557 PMC: 4498192. DOI: 10.1038/srep12069.

8q24 risk alleles and prostate cancer in African-Barbadian men.

Cropp C, Robbins C, Sheng X, Hennis A, Carpten J, Waterman L Prostate. 2014; 74(16):1579-88.

PMID: 25252079 PMC: 4322001. DOI: 10.1002/pros.22871.

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