Impact of Perioperative Peripheral Blood Values on Postoperative Complications After Esophageal Surgery

Overview

Journal Surg Today

Specialty General Surgery

Date 2010 Jun 29

PMID 20582513

Citations 15

Authors

Hiroshi Saeki

Takanobu Masuda

Satoko Okada

Koji Ando

Masahiko Sugiyama

Keiji Yoshinaga

Kazuya Endo

Noriaki Sadanaga

Yasunori Emi

Yoshihiro Kakeji

Masaru Morita

Natsumi Yamashita

Yoshihiko Maehara

Affiliations

Soon will be listed here.

Abstract

Purpose: Prediction of the postoperative course of esophagectomy is an important part of the strict perioperative management of patients undergoing surgery for esophageal cancer.

Methods: To evaluate their clinical importance, peripheral blood values, including white blood cell count (WBC), lymphocyte count, and the levels of total protein, transferrin, factor XIII, D-dimer, fibrin, and fibrinogen degradation products (FDP) were measured before and after esophagectomy for esophageal cancer in 24 patients.

Results: The preoperative WBC and the pre- and postoperative lymphocyte count were decreased remarkably in patients who received preoperative chemoradiotherapy. The values of perioperative serum transferrin were significantly lower in patients with postoperative pneumonia than in those without. The activity of plasma factor XIII was suppressed on postoperative day (POD) 7 in patients with pneumonia and on POD 14 in patients with leakage.

Conclusions: These results suggest that patients who receive preoperative chemoradiotherapy are potentially immunosuppressed, the preoperative serum transferrin level is a possible predictive marker of postoperative pneumonia, and suppression of factor XIII activity is related to anastomotic insufficiency.

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