Mitochondrial Helicases and Mitochondrial Genome Maintenance

Overview

Journal Mech Ageing Dev

Specialty Geriatrics

Date 2010 Jun 26

PMID 20576512

Citations 6

Authors

Nadja C de Souza-Pinto

Maria D Aamann

Tomasz Kulikowicz

Tinna V Stevnsner

Vilhelm A Bohr

Affiliations

Soon will be listed here.

Abstract

Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.

Citing Articles

Boguszewska K, Szewczuk M, Kazmierczak-Baranska J, Karwowski B Molecules. 2020; 25(12).

PMID: 32575813 PMC: 7356350. DOI: 10.3390/molecules25122857.

TWINKLE and Other Human Mitochondrial DNA Helicases: Structure, Function and Disease.

Peter B, Falkenberg M Genes (Basel). 2020; 11(4).

PMID: 32283748 PMC: 7231222. DOI: 10.3390/genes11040408.

Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.

Bannwarth S, Berg-Alonso L, Auge G, Fragaki K, Kolesar J, Lespinasse F Mitochondrion. 2016; 30:126-37.

PMID: 26923168 PMC: 5454384. DOI: 10.1016/j.mito.2016.02.005.

Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.

Wang J, Xu X, Alontaga A, Chen Y, Liu Y Cell Rep. 2014; 7(3):848-58.

PMID: 24746816 PMC: 4029353. DOI: 10.1016/j.celrep.2014.03.037.

Mechanism of homologous recombination and implications for aging-related deletions in mitochondrial DNA.

Chen X Microbiol Mol Biol Rev. 2013; 77(3):476-96.

PMID: 24006472 PMC: 3811608. DOI: 10.1128/MMBR.00007-13.

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