Mib-Jag1-Notch Signalling Regulates Patterning and Structural Roles of the Notochord by Controlling Cell-fate Decisions

Overview

Journal Development

Specialty Biology

Date 2010 Jun 25

PMID 20573700

Citations 49

Authors

Mai Yamamoto

Ryoko Morita

Takamasa Mizoguchi

Hiromi Matsuo

Miho Isoda

Tohru Ishitani

Ajay B Chitnis

Kunihiro Matsumoto

J Gage Crump

Katsuto Hozumi

Shigenobu Yonemura

Koichi Kawakami

Motoyuki Itoh

Affiliations

Soon will be listed here.

Abstract

In the developing embryo, cell-cell signalling is necessary for tissue patterning and structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates the patterning activities and structural integrity of the notochord. We found that Mind bomb (Mib) ubiquitylates Jagged 1 (Jag1) and is essential in the signal-emitting cells for Jag1 to activate Notch signalling. In zebrafish, loss- and gain-of-function analyses showed that Mib-Jag1-Notch signalling favours the development of non-vacuolated cells at the expense of vacuolated cells in the notochord. This leads to changes in the peri-notochordal basement membrane formation and patterning surrounding the muscle pioneer cells. These data reveal a previously unrecognized mechanism regulating the patterning and structural roles of the notochord by Mib-Jag1-Notch signalling-mediated cell-fate determination.

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