Experience with Nerve Allograft Transplantation

Overview

Journal Semin Plast Surg

Specialty General Surgery

Date 2010 Jun 23

PMID 20567677

Citations 10

Authors

Ida K Fox

Susan E Mackinnon

Affiliations

Soon will be listed here.

Abstract

Nerve allograft transplantation should be used for the repair of devastating peripheral nerve injuries that cannot be reconstructed through traditional means such as autologous nerve grafting or nerve transfer procedures. The risks of required systemic immunosuppression, although only temporary for nerve allograft recipients, preclude widespread use of this treatment modality. Translational research has led to several advancements in this field including the use of preoperative allograft cold preservation in University of Wisconsin organ preservation solution and inclusion of tacrolimus as part of the immunosuppressive regimen. Investigation of how to further diminish nerve allograft immunogenicity, speed neuroregeneration by use of agents such as tacrolimus, and promote preferential motor regeneration will further advance this field with the goal of restoring optimal function while minimizing patient morbidity.

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References

Evans P, Mackinnon S, Levi A, Wade J, Hunter D, Nakao Y . Cold preserved nerve allografts: changes in basement membrane, viability, immunogenicity, and regeneration. Muscle Nerve. 1998; 21(11):1507-22. DOI: 10.1002/(sici)1097-4598(199811)21:11<1507::aid-mus21>3.0.co;2-w. View

Wang M, Gold B . Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve. J Pharmacol Exp Ther. 1997; 282(2):1084-93. View

Gold B, Gordon H, Wang M . Efficacy of delayed or discontinuous FK506 administrations on nerve regeneration in the rat sciatic nerve crush model: lack of evidence for a conditioning lesion-like effect. Neurosci Lett. 1999; 267(1):33-6. DOI: 10.1016/s0304-3940(99)00333-x. View

Hricik D . Withdrawal of immunosuppression: implications for composite tissue allograft transplantation. Transplant Proc. 1998; 30(6):2721-3. DOI: 10.1016/s0041-1345(98)00796-9. View

Best T, Mackinnon S, Midha R, Hunter D, Evans P . Revascularization of peripheral nerve autografts and allografts. Plast Reconstr Surg. 1999; 104(1):152-60. View

Genden E, Mackinnon S, Yu S, Hunter D, Flye M . Pretreatment with portal venous ultraviolet B-irradiated donor alloantigen promotes donor-specific tolerance to rat nerve allografts. Laryngoscope. 2001; 111(3):439-47. DOI: 10.1097/00005537-200103000-00012. View

Fansa H, Lassner F, Kook P, Keilhoff G, Schneider W . Cryopreservation of peripheral nerve grafts. Muscle Nerve. 2000; 23(8):1227-33. DOI: 10.1002/1097-4598(200008)23:8<1227::aid-mus11>3.0.co;2-6. View

Mosahebi A, Wiberg M, Terenghi G . Addition of fibronectin to alginate matrix improves peripheral nerve regeneration in tissue-engineered conduits. Tissue Eng. 2003; 9(2):209-18. DOI: 10.1089/107632703764664684. View

Hare G, Evans P, Mackinnon S, Wade J, YOUNG A, Hay J . Phenotypic analysis of migrant, efferent lymphocytes after implantation of cold preserved, peripheral nerve allografts. J Neuroimmunol. 1995; 56(1):9-16. DOI: 10.1016/0165-5728(94)00120-d. View

10.

Mackinnon S, Hudson A, Falk R, Bilbao J, Kline D, Hunter D . Nerve allograft response: a quantitative immunological study. Neurosurgery. 1982; 10(1):61-9. DOI: 10.1227/00006123-198201000-00011. View

11.

Fansa H, Keilhoff G, Altmann S, Plogmeier K, Wolf G, Schneider W . The effect of the immunosuppressant FK 506 on peripheral nerve regeneration following nerve grafting. J Hand Surg Br. 1999; 24(1):38-42. DOI: 10.1016/s0266-7681(99)90021-9. View

12.

Mackinnon S, Doolabh V, Novak C, Trulock E . Clinical outcome following nerve allograft transplantation. Plast Reconstr Surg. 2001; 107(6):1419-29. DOI: 10.1097/00006534-200105000-00016. View

13.

Brenner M, Tung T, Mackinnon S, Myckatyn T, Hunter D, Mohanakumar T . Anti-CD40 ligand monoclonal antibody induces a permissive state, but not tolerance, for murine peripheral nerve allografts. Exp Neurol. 2004; 186(1):59-69. DOI: 10.1016/j.expneurol.2003.10.002. View

14.

Lee M, Doolabh V, Mackinnon S, Jost S . FK506 promotes functional recovery in crushed rat sciatic nerve. Muscle Nerve. 2000; 23(4):633-40. DOI: 10.1002/(sici)1097-4598(200004)23:4<633::aid-mus24>3.0.co;2-q. View

15.

Mackinnon S, Hudson A, Falk R, Kline D, Hunter D . Peripheral nerve allograft: an assessment of regeneration across pretreated nerve allografts. Neurosurgery. 1984; 15(5):690-3. DOI: 10.1227/00006123-198411000-00009. View

16.

Pollard J, Gye R, McLeod J . An assessment of immunosuppressive agents in experimental peripheral nerve transplantation. Surg Gynecol Obstet. 1971; 132(5):839-45. View

17.

Gold B, Densmore V, Shou W, Matzuk M, Gordon H . Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. J Pharmacol Exp Ther. 1999; 289(3):1202-10. View

18.

Ansselin A, Pollard J . Immunopathological factors in peripheral nerve allograft rejection: quantification of lymphocyte invasion and major histocompatibility complex expression. J Neurol Sci. 1990; 96(1):75-88. DOI: 10.1016/0022-510x(90)90058-u. View

19.

Levi A, Guenard V, Aebischer P, Bunge R . The functional characteristics of Schwann cells cultured from human peripheral nerve after transplantation into a gap within the rat sciatic nerve. J Neurosci. 1994; 14(3 Pt 1):1309-19. PMC: 6577549. View

20.

Komiyama T, Nakao Y, Toyama Y, Vacanti C, Vacanti M, Ignotz R . Novel technique for peripheral nerve reconstruction in the absence of an artificial conduit. J Neurosci Methods. 2004; 134(2):133-40. DOI: 10.1016/j.jneumeth.2003.11.020. View