The Role of Pleiotrophin and Beta-catenin in Fetal Lung Development

Overview

Journal Respir Res

Specialty Pulmonary Medicine

Date 2010 Jun 23

PMID 20565841

Citations 15

Authors

Tingting Weng

Lin Liu

Affiliations

Soon will be listed here.

Abstract

Mammalian lung development is a complex biological process, which is temporally and spatially regulated by growth factors, hormones, and extracellular matrix proteins. Abnormal changes of these molecules often lead to impaired lung development, and thus pulmonary diseases. Epithelial-mesenchymal interactions are crucial for fetal lung development. This paper reviews two interconnected pathways, pleiotrophin and Wnt/beta-catenin, which are involved in fibroblast and epithelial cell communication during fetal lung development.

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