Directed Stem Cell Differentiation: the Role of Physical Forces

Overview

Journal Cell Commun Adhes

Specialty Cell Biology

Date 2010 Jun 22

PMID 20560867

Citations 31

Authors

Kelly C Clause

Li J Liu

Kimimasa Tobita

Affiliations

Soon will be listed here.

Abstract

A number of factors contribute to the control of stem cell fate. In particular, the evidence for how physical forces control the stem cell differentiation program is now accruing. In this review, the authors discuss the types of physical forces: mechanical forces, cell shape, extracellular matrix geometry/properties, and cell-cell contacts and morphogenic factors, which evidence suggests play a role in influencing stem cell fate.

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References

Tsai R, McKay R . Cell contact regulates fate choice by cortical stem cells. J Neurosci. 2000; 20(10):3725-35. PMC: 6772699. View

Sze S, de Kleijn D, Lai R, Tan E, Zhao H, Yeo K . Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007; 6(10):1680-9. DOI: 10.1074/mcp.M600393-MCP200. View

Shimizu N, Yamamoto K, Obi S, Kumagaya S, Masumura T, Shimano Y . Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor beta. J Appl Physiol (1985). 2008; 104(3):766-72. DOI: 10.1152/japplphysiol.00870.2007. View

Park J, Chu J, Cheng C, Chen F, Chen D, Li S . Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells. Biotechnol Bioeng. 2004; 88(3):359-68. DOI: 10.1002/bit.20250. View

Hwang N, Varghese S, Zhang Z, Elisseeff J . Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels. Tissue Eng. 2006; 12(9):2695-706. DOI: 10.1089/ten.2006.12.2695. View

Kluger Y, Tuck D, Chang J, Nakayama Y, Poddar R, Kohya N . Lineage specificity of gene expression patterns. Proc Natl Acad Sci U S A. 2004; 101(17):6508-13. PMC: 404075. DOI: 10.1073/pnas.0401136101. View

Tang J, Peng R, Ding J . The regulation of stem cell differentiation by cell-cell contact on micropatterned material surfaces. Biomaterials. 2009; 31(9):2470-6. DOI: 10.1016/j.biomaterials.2009.12.006. View

Hoben G, Koay E, Athanasiou K . Fibrochondrogenesis in two embryonic stem cell lines: effects of differentiation timelines. Stem Cells. 2007; 26(2):422-30. DOI: 10.1634/stemcells.2007-0641. View

Saha S, Ji L, de Pablo J, Palecek S . Inhibition of human embryonic stem cell differentiation by mechanical strain. J Cell Physiol. 2005; 206(1):126-37. DOI: 10.1002/jcp.20441. View

10.

Johnstone B, Hering T, Caplan A, Goldberg V, Yoo J . In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. 1998; 238(1):265-72. DOI: 10.1006/excr.1997.3858. View

11.

Yang Y, Beqaj S, Kemp P, Ariel I, Schuger L . Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia. J Clin Invest. 2000; 106(11):1321-30. PMC: 387248. DOI: 10.1172/JCI8893. View

12.

Hadjipanayi E, Mudera V, BROWN R . Close dependence of fibroblast proliferation on collagen scaffold matrix stiffness. J Tissue Eng Regen Med. 2008; 3(2):77-84. DOI: 10.1002/term.136. View

13.

Gerstenfeld L, Barnes G, Shea C, Einhorn T . Osteogenic differentiation is selectively promoted by morphogenetic signals from chondrocytes and synergized by a nutrient rich growth environment. Connect Tissue Res. 2003; 44 Suppl 1:85-91. View

14.

Hayman M, Smith K, Cameron N, Przyborski S . Growth of human stem cell-derived neurons on solid three-dimensional polymers. J Biochem Biophys Methods. 2005; 62(3):231-40. DOI: 10.1016/j.jbbm.2004.12.001. View

15.

Yamamoto K, Takahashi T, Asahara T, Ohura N, Sokabe T, Kamiya A . Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress. J Appl Physiol (1985). 2003; 95(5):2081-8. DOI: 10.1152/japplphysiol.00232.2003. View

16.

Huang C, Hagar K, Frost L, Sun Y, Cheung H . Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells. 2004; 22(3):313-23. DOI: 10.1634/stemcells.22-3-313. View

17.

McBeath R, Pirone D, Nelson C, Bhadriraju K, Chen C . Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell. 2004; 6(4):483-95. DOI: 10.1016/s1534-5807(04)00075-9. View

18.

Altman G, Horan R, Martin I, Farhadi J, Stark P, Volloch V . Cell differentiation by mechanical stress. FASEB J. 2002; 16(2):270-2. DOI: 10.1096/fj.01-0656fje. View

19.

Recknor J, Sakaguchi D, Mallapragada S . Directed growth and selective differentiation of neural progenitor cells on micropatterned polymer substrates. Biomaterials. 2006; 27(22):4098-108. DOI: 10.1016/j.biomaterials.2006.03.029. View

20.

Griffith L, Swartz M . Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol. 2006; 7(3):211-24. DOI: 10.1038/nrm1858. View