Intramyocardial Navigation and Mapping for Stem Cell Delivery

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2010 Jun 19

PMID 20560027

Citations 12

Authors

Peter J Psaltis

Andrew C W Zannettino

Stan Gronthos

Stephen G Worthley

Affiliations

Soon will be listed here.

Abstract

Method for delivery remains a central component of stem cell-based cardiovascular research. Comparative studies have demonstrated the advantages of administering cell therapy directly into the myocardium, as distinct from infusing cells into the systemic or coronary vasculature. Intramyocardial delivery can be achieved either transepicardially or transendocardially. The latter involves percutaneous, femoral arterial access and the retrograde passage of specially designed injection catheters into the left ventricle, making it less invasive and more relevant to wider clinical practice. Imaging-based navigation plays an important role in guiding catheter manipulation and directing endomyocardial injections. The most established strategy for three-dimensional, intracardiac navigation is currently endoventricular, electromechanical mapping, which offers superior spatial orientation compared to simple x-ray fluoroscopy. Its provision of point-by-point, electrophysiologic and motion data also allows characterization of regional myocardial viability, perfusion, and function, especially in the setting of ischemic heart disease. Integrating the mapping catheter with an injection port enables this diagnostic information to facilitate the targeting of intramyocardial stem cell delivery. This review discusses the diagnostic accuracy and expanding therapeutic application of electromechanical navigation in cell-based research and describes exciting developments which will improve the technology's sensing capabilities, image registration, and delivery precision in the near future.

Citing Articles

Nuclear Cardiac Imaging in the Interventional Suite.

Pickell Z, Sinusas A Curr Cardiol Rep. 2022; 24(3):261-269.

PMID: 35028819 PMC: 8934268. DOI: 10.1007/s11886-022-01644-1.

Stem cell therapy for dilated cardiomyopathy.

Diaz-Navarro R, Urrutia G, Cleland J, Poloni D, Villagran F, Acosta-Dighero R Cochrane Database Syst Rev. 2021; 7:CD013433.

PMID: 34286511 PMC: 8406792. DOI: 10.1002/14651858.CD013433.pub2.

Pilot Study of Endovascular Delivery of Mesenchymal Stromal Cells in the Aortic Wall in a Pig Model.

Li K, Vela D, Migliati E, da Graca Cabreira M, Wang X, Buja L Cell Transplant. 2021; 30:9636897211010652.

PMID: 33938770 PMC: 8114770. DOI: 10.1177/09636897211010652.

3D Myocardial Scar Prediction Model Derived from Multimodality Analysis of Electromechanical Mapping and Magnetic Resonance Imaging.

van den Broek H, Wenker S, van de Leur R, Doevendans P, Chamuleau S, van Slochteren F J Cardiovasc Transl Res. 2019; 12(6):517-527.

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Cellular Therapy for Heart Failure.

Psaltis P, Schwarz N, Toledo-Flores D, Nicholls S Curr Cardiol Rev. 2016; 12(3):195-215.

PMID: 27280304 PMC: 5011188. DOI: 10.2174/1573403x12666160606121858.

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