Roles of Vpr and Vpx in Modulating the Virus-host Cell Relationship

Overview

Journal Mol Aspects Med

Specialties Biochemistry
Molecular Biology

Date 2010 Jun 19

PMID 20558198

Citations 15

Authors

Vicente Planelles

Edward Barker

Affiliations

Soon will be listed here.

Abstract

The human and simian immunodeficiency viruses contain small open reading frames known as vpr and vpx. These genes encode proteins that are highly related both at the amino acid level and functionally, although key differences do exist. This review describes the main functions ascribed to Vpr and Vpx in the context of both viral replication and modulation of host cell biology.

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