Synthesis and Antiproliferative Activity of Coumarin-estrogen Conjugates Against Breast Cancer Cell Lines

Overview

Journal Lett Drug Des Discov

Publisher Bentham Science Publishers

Date 2010 Jun 18

PMID 20556210

Citations 9

Authors

Musiliyu A Musa

M Omar F Khan

John S Cooperwood

Affiliations

Soon will be listed here.

Abstract

The syntheses and cytotoxic activity of coumarin-estrogen conjugates are described. In vitro results indicated that conjugates 10, 11 and 13 show growth inhibitory activities at 5-dose concentration (100, 10, 1, 0.1, 0.01 muM) against the following NCI-7- human breast cancer cell lines: BT-549, HS 578T, MCF 7, MDA-MB-231/ATCC, MDA-MB-435, NCI/ADR-RES, and thus serve as new leads for further development of antibreast cancer agent.

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