Using Serological Measures to Monitor Changes in Malaria Transmission in Vanuatu

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2010 Jun 18

PMID 20553604

Citations 116

Authors

Jackie Cook

Heidi Reid

Jennifer Iavro

Melissa Kuwahata

George Taleo

Archie Clements

James McCarthy

Andrew Vallely

Chris Drakeley

Affiliations

Soon will be listed here.

Abstract

Background: With renewed interest in malaria elimination, island environments present unique opportunities to achieve this goal. However, as transmission decreases, monitoring and evaluation programmes need increasingly sensitive tools to assess Plasmodium falciparum and Plasmodium vivax exposure. In 2009, to assess the role of serological markers in evaluating malaria transmission, a cross-sectional seroprevalence study was carried out in Tanna and Aneityum, two of the southernmost islands of the Vanuatu archipelago, areas where malaria transmission has been variably reduced over the past few decades.

Methods: Malaria transmission was assessed using serological markers for exposure to P. falciparum and P. vivax. Filter blood spot papers were collected from 1,249 people from Tanna, and 517 people from Aneityum to assess the prevalence of antibodies to two P. falciparum antigens (MSP-119 and AMA-1) and two P. vivax antigens (MSP-119 and AMA-1). Age-specific prevalence was modelled using a simple catalytic conversion model based on maximum likelihood to generate a community seroconversion rate (SCR).

Results: Overall seropositivity in Tanna was 9.4%, 12.4% and 16.6% to P. falciparum MSP-119, AMA-1 and Schizont Extract respectively and 12.6% and 15.0% to P. vivax MSP-119 and AMA-1 respectively. Serological results distinguished between areas of differential dominance of either P. vivax or P. falciparum and analysis of age-stratified results showed a step in seroprevalence occurring approximately 30 years ago on both islands, indicative of a change in transmission intensity at this time. Results from Aneityum suggest that several children may have been exposed to malaria since the 2002 P. vivax epidemic.

Conclusion: Seroepidemiology can provide key information on malaria transmission for control programmes, when parasite rates are low. As Vanuatu moves closer to malaria elimination, monitoring changes in transmission intensity and identification of residual malaria foci is paramount in order to concentrate intervention efforts.

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References

Williams G, Mweya C, Stewart L, Mtove G, Reyburn H, Cook J . Immunophoretic rapid diagnostic tests as a source of immunoglobulins for estimating malaria sero-prevalence and transmission intensity. Malar J. 2009; 8:168. PMC: 2720984. DOI: 10.1186/1475-2875-8-168. View

Mathews H, Storey J, Ashkar T, Brogger S, MOLINEAUX L . Changing patterns in the humoral immune response to malaria before, during, and after the application of control measures: a longitudinal study in the West African savanna. Bull World Health Organ. 1978; 56(4):579-600. PMC: 2395642. View

Voller A, Storey J, MOLINEAUX L . A longitudinal study of Plasmodium falciparum malaria in the West African savannah using the ELISA technique. Bull World Health Organ. 1980; 58(3):429-38. PMC: 2395907. View

Ambroise-Thomas P, Wernsdorfer W, GRAB B, Cullen J, BERTAGNA P . [Longitudinal sero-epidemiologic study of malaria in Tunisia]. Bull World Health Organ. 1976; 54(4):355-67. PMC: 2366475. View

Gaffar F, Yatsuda A, Franssen F, de Vries E . Erythrocyte invasion by Babesia bovis merozoites is inhibited by polyclonal antisera directed against peptides derived from a homologue of Plasmodium falciparum apical membrane antigen 1. Infect Immun. 2004; 72(5):2947-55. PMC: 387893. DOI: 10.1128/IAI.72.5.2947-2955.2004. View

Voller A, BRUCE-CHWATT L . Serological malaria surveys in Nigeria. Bull World Health Organ. 1968; 39(6):883-97. PMC: 2554577. View

Mendis K, Sina B, Marchesini P, Carter R . The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg. 2001; 64(1-2 Suppl):97-106. DOI: 10.4269/ajtmh.2001.64.97. View

Lin E, Kiniboro B, Gray L, Dobbie S, Robinson L, Laumaea A . Differential patterns of infection and disease with P. falciparum and P. vivax in young Papua New Guinean children. PLoS One. 2010; 5(2):e9047. PMC: 2816213. DOI: 10.1371/journal.pone.0009047. View

Bockarie M, Dagoro H . Are insecticide-treated bednets more protective against Plasmodium falciparum than Plasmodium vivax-infected mosquitoes?. Malar J. 2006; 5:15. PMC: 1388224. DOI: 10.1186/1475-2875-5-15. View

10.

Elissa N, Migot-Nabias F, Luty A, Renaut A, Toure F, Vaillant M . Relationship between entomological inoculation rate, Plasmodium falciparum prevalence rate, and incidence of malaria attack in rural Gabon. Acta Trop. 2003; 85(3):355-61. DOI: 10.1016/s0001-706x(02)00266-8. View

11.

Maitland K, Williams T, Bennett S, Newbold C, Peto T, Viji J . The interaction between Plasmodium falciparum and P. vivax in children on Espiritu Santo island, Vanuatu. Trans R Soc Trop Med Hyg. 1996; 90(6):614-20. DOI: 10.1016/s0035-9203(96)90406-x. View

12.

Akpogheneta O, Duah N, Tetteh K, Dunyo S, Lanar D, Pinder M . Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific. Infect Immun. 2008; 76(4):1748-55. PMC: 2292892. DOI: 10.1128/IAI.01333-07. View

13.

Nagelkerke N, Borgdorff M, Kim S . Logistic discrimination of mixtures of M. tuberculosis and non-specific tuberculin reactions. Stat Med. 2001; 20(7):1113-24. DOI: 10.1002/sim.745. View

14.

Drakeley C, Cook J . Chapter 5. Potential contribution of sero-epidemiological analysis for monitoring malaria control and elimination: historical and current perspectives. Adv Parasitol. 2009; 69:299-352. DOI: 10.1016/S0065-308X(09)69005-9. View

15.

Abramo C, Fontes C, Krettli A . Cross-reactivity between antibodies in the sera of individuals with leishmaniasis, toxoplasmosis, and Chagas' disease and antigens of the blood-stage forms of Plasmodium falciparum determined by indirect immunofluorescence. Am J Trop Med Hyg. 1995; 53(2):202-5. DOI: 10.4269/ajtmh.1995.53.202. View

16.

Gray D, Forsyth S, Li R, McManus D, Li Y, Chen H . An innovative database for epidemiological field studies of neglected tropical diseases. PLoS Negl Trop Dis. 2009; 3(5):e413. PMC: 2680951. DOI: 10.1371/journal.pntd.0000413. View

17.

BRUCE-CHWATT L, Draper C, Avramidis D, Kazandzoglou O . Sero-epidemiological surveillance of disappearing malaria in Greece. J Trop Med Hyg. 1975; 78(9):194-200. View

18.

BRUCE-CHWATT L, Draper C, Konfortion P . Seroepidemiological evidence of eradication of malaria from Mauritius. Lancet. 1973; 2(7828):547-51. DOI: 10.1016/s0140-6736(73)92361-1. View

19.

Stewart L, Gosling R, Griffin J, Gesase S, Campo J, Hashim R . Rapid assessment of malaria transmission using age-specific sero-conversion rates. PLoS One. 2009; 4(6):e6083. PMC: 2698122. DOI: 10.1371/journal.pone.0006083. View

20.

Donahue C, Carruthers V, Gilk S, Ward G . The Toxoplasma homolog of Plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels. Mol Biochem Parasitol. 2000; 111(1):15-30. DOI: 10.1016/s0166-6851(00)00289-9. View