Late Auditory Event-related Evoked Potential (P300) in Down's Syndrome Patients

Overview

Journal Braz J Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2010 Jun 16

PMID 20549081

Citations 6

Authors

Carla Patricia Hernandez Alves Ribeiro Cesar

Heloisa Helena Caovilla

Mario Sergio Lei Munhoz

Mauricio Malavasi Gananca

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Down syndrome is caused by a trisomy of chromosome 21 and is associated with central auditory processing deficit, learning disability and, probably, early-onset Alzheimer's disease.

Aim: To evaluate the latencies and amplitudes of evoked late auditory potential related to P300 events and their changes in young adults with Down's syndrome.

Materials And Methods: Prospective case study. P300 test latency and amplitudes were evaluated in 17 individuals with Down's syndrome and 34 healthy individuals. RESULTS The P300 latency (N1, P2, N2 and P3) was longer and the N2-P3 amplitude was lower in individuals with Down syndrome when compared to those in the control group.

Conclusion: In young adults with Down syndrome, N1, P2, N2 and P3 latencies of late auditory evoked potential related to P300 events were prolonged, and N2 - P3 amplitudes were significantly reduced, suggesting integration impairment between the auditory association area and cortical and subcortical areas of the central nervous system.

Citing Articles

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Saini F, Masina F, Wells J, Rosch R, Hamburg S, Startin C Cereb Cortex. 2023; 33(16):9639-9651.

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Hearing impairment in murine model of Down syndrome.

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Applicability of the P300 frequency pattern test to assess auditory processing.

Mendonca E, Muniz L, Leal M, Diniz A Braz J Otorhinolaryngol. 2013; 79(4):512-21.

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