Molecular Epidemiology of Japanese Encephalitis Virus Circulating in South Korea, 1983-2005

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2010 Jun 16

PMID 20546562

Citations 36

Authors

Seok-Min Yun

Jung Eun Cho

Young-Ran Ju

Su Yeon Kim

Jungsang Ryou

Myung Guk Han

Woo-Young Choi

Young Eui Jeong

Affiliations

Soon will be listed here.

Abstract

We sequenced the envelope (E) gene of 17 strains of the Japanese encephalitis virus (JEV) isolated in South Korea in 1983-2005 and compared the sequences with those from previously reported strains. Our results show the remarkable genetic stability of the E gene sequence in Korean JEV strains. Five pairs of E gene sequences from 10 Korean strains were identical, despite geographical differences and a maximum five-year time span. Sequence comparisons with other Asian strains revealed that the Korean strains are closely related to those from China, Japan, and Vietnam. Genotype 3 strains were predominant in Korea before 1993, when genotype 1 strain K93A07 was first isolated. The two genotypes were detected simultaneously in 1994 but since then, only genotype 1 has been isolated in South Korea. Thus, the genotype change occurred according to the year of isolation rather than the geographical origin.

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