Cerebellar Involvement in Hodgkin's Lymphoma: an Atypical Site of Relapse

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2010 Jun 11

PMID 20534402

Citations 1

Authors

Aurora Sanz

Angel Montero

Clara Salas

Enrique Amaya

Gemma Rodriguez

Rosa Magallon

Alejandro De La Torre

Affiliations

Soon will be listed here.

Abstract

The presentation of intracranial metastases from Hodgkin's lymphoma is an infrequent event that worsens clinical outcome. A case of Hodgkin's lymphoma relapse in the cerebellum is described in a 70-year-old woman with a previously treated stage IVA Hodgkin's lymphoma. Diagnostic workup and treatment strategies for central nervous system relapses are reviewed and discussed. A combination of surgery, radiotherapy and occasionally chemotherapy remains the most appropriate approach to intracranial Hodgkin's lymphoma.

Citing Articles

Hodgkin's disease presenting as discharging neck sinuses and a mediastinal mass.

Zolotar M, Olaleye O, Sherif A, Howe R, Mathews J BMJ Case Rep. 2012; 2011.

PMID: 22689859 PMC: 3149508. DOI: 10.1136/bcr.12.2010.3669.

References

Morawa E, Ragam A, Sirota R, Nabhan C . Hodgkin's lymphoma involving the CNS. J Clin Oncol. 2007; 25(11):1437-8. DOI: 10.1200/JCO.2006.10.1691. View

Cavalli F . Rare syndromes in Hodgkin's disease. Ann Oncol. 1999; 9 Suppl 5:S109-13. DOI: 10.1093/annonc/9.suppl_5.s109. View

Ramirez C, Reyns N, Ayachi M, Blond S . [Isolated intracranial relapse in previously treated Hodgkin's disease]. Rev Neurol (Paris). 2009; 165(11):984-7. DOI: 10.1016/j.neurol.2009.01.043. View

Apollonsky N, Edelman M, Johnson A, Bhuiya T, Karayalcin G . Intracerebral presentation of Hodgkin disease mimicking meningioma in a young woman: case presentation with literature review. J Pediatr Hematol Oncol. 2008; 30(5):369-72. DOI: 10.1097/MPH.0b013e31816392b7. View

Biagi J, MacKenzie R, Lim M, Sapp M, Berinstein N . Primary Hodgkin's disease of the CNS in an immunocompetent patient: a case study and review of the literature. Neuro Oncol. 2001; 2(4):239-43. PMC: 1920596. DOI: 10.1093/neuonc/2.4.239. View

Alkhalil A, Elziere C, Kelaidi C, Belin C, Salama J . [Intracranial localization revealing Hodgkin's disease]. Rev Neurol (Paris). 2008; 164(2):200-5. DOI: 10.1016/j.neurol.2007.09.002. View

Akyuz C, Yalcin B, Atahan I, Varan A, Kutluk M, Buyukpamukcu M . Intracranial involvement in Hodgkin's disease. Pediatr Hematol Oncol. 2005; 22(7):589-96. DOI: 10.1080/08880010500198863. View

Herrlinger U, Klingel K, Meyermann R, Kandolf R, Kaiserling E, Kortmann R . Central nervous system Hodgkin's lymphoma without systemic manifestation: case report and review of the literature. Acta Neuropathol. 2000; 99(6):709-14. DOI: 10.1007/s004010051185. View

Gupta V, Ghosh J, Pant P, Bhatia B . Intracranial Hodgkin's disease. Indian J Pediatr. 2006; 73(4):370-1. DOI: 10.1007/BF02825839. View

10.

Re D, Fuchs M, Schober T, Engert A, Diehl V . CNS involvement in Hodgkin's lymphoma. J Clin Oncol. 2007; 25(21):3182. DOI: 10.1200/JCO.2007.12.5088. View

11.

Corti M, Fioti M, Yampolsky C, Schtirbu R, Narbaitz M . Central nervous system involvement in Hodgkin's lymphoma associated with Epstein-Barr virus in a patient with AIDS: case report and review of the literature. Braz J Infect Dis. 2007; 10(6):403-5. DOI: 10.1590/s1413-86702006000600009. View

12.

Nakayama H, Tokuuye K, Kagami Y, Sumi M, Murayama S, Kawashima M . Brain involvement in Hodgkin's disease: case reports and review of the literature. Radiat Med. 2000; 18(3):205-8. View

13.

Garcia-Noblejas A, Nieto S, Liberal R, Cannata J, Steegmann J, Fernandez-Ranada J . Intracerebral Hodgkin's lymphoma in a patient with human immunodeficiency virus. Haematologica. 2007; 92(6):e72-3. DOI: 10.3324/haematol.11291. View

14.

Gerstner E, Abrey L, Schiff D, Ferreri A, Lister A, Montoto S . CNS Hodgkin lymphoma. Blood. 2008; 112(5):1658-61. PMC: 3710443. DOI: 10.1182/blood-2008-04-151563. View

15.

SPARLING Jr H, Adams R . Primary Hodgkin's sarcoma of the brain. Arch Pathol (Chic). 2010; 42:338-44. View