Insulin Resistance and Its Association with the Components of the Metabolic Syndrome Among Obese Children and Adolescents

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2010 Jun 10

PMID 20529295

Citations 35

Authors

Carlos Juarez-Lopez

Miguel Klunder-Klunder

Patricia Medina-Bravo

Adrian Madrigal-Azcarate

Eliezer Mass-Diaz

Samuel Flores-Huerta

Affiliations

Soon will be listed here.

Abstract

Background: Insulin resistance is the primary metabolic disorder associated with obesity; yet little is known about its role as a determinant of the metabolic syndrome in obese children. The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among obese children and adolescents.

Methods: An analytical, cross-sectional and population-based study was performed in forty-four public primary schools in Campeche City, Mexico. A total of 466 obese children and adolescents between 11-13 years of age were recruited. Fasting glucose and insulin concentrations, high density lipoprotein cholesterol, triglycerides, waist circumference, systolic and diastolic blood pressures were measured; insulin resistance and metabolic syndrome were also evaluated.

Results: Out of the total population studied, 69% presented low values of high density lipoprotein cholesterol, 49% suffered from abdominal obesity, 29% had hypertriglyceridemia, 8% presented high systolic and 13% high diastolic blood pressure, 4% showed impaired fasting glucose, 51% presented insulin resistance and 20% metabolic syndrome. In spite of being obese, 13% of the investigated population did not present any metabolic disorder. For each one of the components of the metabolic syndrome, when insulin resistance increased so did odds ratios as cardiometabolic risk factors.

Conclusions: Regardless of age and gender an increased degree of insulin resistance is associated with a higher prevalence of disorders in each of the components of the metabolic syndrome and with a heightened risk of suffering metabolic syndrome among obese children and adolescents.

Citing Articles

Comparison of the Clinical Utility of Two Insulin Resistance Indices: IRI-HOMA and IRI-Belfiore in Diagnosing Insulin Resistance and Metabolic Complications in Children Based on the Results Obtained for the Polish Population.

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Sociodemographic inequalities in cardiovascular risk factors among adolescents from indigenous areas in Chiapas, Mexico.

Flores-Guillen E, Castro-Quezada I, Irecta-Najera C, Nunez-Ortega P, Solis-Hernandez R, Garcia-Miranda R Cad Saude Publica. 2023; 39(11):e00024623.

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Assessment of Biochemical Parameters in 8- and 9-Year-Old Children with Excessive Body Weight Participating in a Year-Long Intervention Program.

Raducha D, Ratajczak J, Kostrzeba E, Berus E, Walczak M, Petriczko E J Clin Med. 2023; 12(20).

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Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats.

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Are glucose and insulin levels at all time points during OGTT a reliable marker of diabetes mellitus risk in pediatric obesity?.

La Valle A, dAnnunzio G, Campanello C, Tantari G, Pistorio A, Napoli F J Endocrinol Invest. 2023; 46(8):1685-1694.

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