» Articles » PMID: 20525897

Signaling Pathways in T Follicular Helper Cells

Overview
Journal J Immunol
Date 2010 Jun 8
PMID 20525897
Citations 23
Authors
Affiliations
Soon will be listed here.
Abstract

Th cell functional subsets have unique transcriptional programs that form the molecular basis for T cell differentiation and functions. T follicular helper (TFH) cells have emerged as the main providers of T cell help to B cells during the germinal center (GC) reaction, where B cells undergo selection events through competition for Ag and for access to GC T cell-mediated prosurvival and differentiation signals. Because T cell help is one limiting factor for GC B cells, the molecular mechanisms controlling TFH cell abundance and functionality are central to the GC reaction and generation of long-term humoral immunity. Two signaling pathways are absolutely critical for TFH cells: phosphoinositide-3 kinase pathway and the signaling lymphocyte activation molecule-associated protein. In this review, the molecular mechanisms constituting the signaling network in TFH cells will be explored.

Citing Articles

Germinal Center T follicular helper (GC-Tfh) cell impairment in chronic HIV infection involves c-Maf signaling.

Chakhtoura M, Fang M, Cubas R, OConnor M, Nichols C, Richardson B PLoS Pathog. 2021; 17(7):e1009732.

PMID: 34280251 PMC: 8289045. DOI: 10.1371/journal.ppat.1009732.


Peripheral T cell lymphomas: from the bench to the clinic.

Fiore D, Cappelli L, Broccoli A, Zinzani P, Chan W, Inghirami G Nat Rev Cancer. 2020; 20(6):323-342.

PMID: 32249838 DOI: 10.1038/s41568-020-0247-0.


PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity.

Preite S, Huang B, Cannons J, McGavern D, Schwartzberg P Front Immunol. 2019; 9:3079.

PMID: 30666254 PMC: 6330320. DOI: 10.3389/fimmu.2018.03079.


C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans.

Verghese D, Chun N, Paz K, Fribourg M, Woodruff T, Flynn R JCI Insight. 2018; 3(24).

PMID: 30568034 PMC: 6338317. DOI: 10.1172/jci.insight.124646.


Molecular Control of Follicular Helper T cell Development and Differentiation.

Wu H, Deng Y, Zhao M, Zhang J, Zheng M, Chen G Front Immunol. 2018; 9:2470.

PMID: 30410493 PMC: 6209674. DOI: 10.3389/fimmu.2018.02470.