Reibergram of Intrathecal Synthesis of C4 in Patients with Eosinophilic Meningitis Caused by Angiostrongylus Cantonensis

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2010 Jun 4

PMID 20519605

Citations 3

Authors

Barbara Padilla-Docal

Alberto Juan Dorta-Contreras

Raisa Bu-Coifiu-Fanego

Alexis Rodriguez-Rey

Juan Carlos Gutierrez-Hernandez

Susana Olga de Paula-Almeida

Affiliations

Soon will be listed here.

Abstract

Angiostrongylus cantonensis produces eosinophilic meningitis in humans and is endemic in Thailand, Taiwan, China, and the Caribbean region. During infection with this parasite, it is important to know if the complement system may be activated by the classical or lectin pathway. Cerebrospinal fluid and serum samples from 20 patients with meningitic angiostrongyliasis were used to quantify C4 levels and albumin. Results were plotted on a C4 CSF/serum quotient diagram or Reibergram. Twelve patients showed intrathecal synthesis of C4. Antibody-dependent complement cytotoxicity should be considered as a possible mechanism that destroys third-stage larvae of this helminth in cerebrospinal fluid of affected patients.

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