The Wild-type Hepatitis C Virus Core Inhibits Initiation of Antigen-specific T- and B-cell Immune Responses in BALB/c Mice

Overview

Journal Clin Vaccine Immunol

Publisher American Society for Microbiology

Specialties Allergy & Immunology
Pathology

Date 2010 Jun 4

PMID 20519445

Citations 9

Authors

Wenbo Zhu

Yanzi Chang

Chunchen Wu

Qingxia Han

Rongjuan Pei

Mengji Lu

Xinwen Chen

Affiliations

Soon will be listed here.

Abstract

In this study, the effects of wild-type and deletion mutant hepatitis C virus (HCV) core proteins on the induction of immune responses in BALB/c mice were assessed. p2HA-C145-S23, encoding a core protein with the C-terminal 46 amino acids truncated, significantly produced stronger antibody and cellular responses than p2HA-C191-S23. The induction of immune responses by p2HA-C145-S23 was dose dependent. However, increasing the doses or repeated administration did not enhance immune responses by the wild-type core protein. In addition, p2HA-C191-S23 was apparently able to interfere with the priming of specific immune responses by p2HA-C145-S23 when the two were coadministered. These results demonstrated that the wild-type HCV core protein itself could inhibit the priming of immune responses in the course of a DNA vaccination, whereas the truncated HCV core protein could provide potential applications for the development of DNA- and peptide-based HCV vaccines.

Citing Articles

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The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response.

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Evaluation of cellular responses for a chimeric HBsAg-HCV core DNA vaccine in BALB/c mice.

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